SOCS1 Deficiency Results in Accelerated Mammary Gland Development and Rescues Lactation in Prolactin Receptor-deficient Mice

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2001 Jul 11

PMID 11445538

Citations 28

Authors

G J Lindeman

S Wittlin

H Lada

M J Naylor

M Santamaria

J G Zhang

R Starr

D J Hilton

W S Alexander

C J Ormandy

J Visvader

Affiliations

Soon will be listed here.

Abstract

Prolactin is essential for proliferation and differentiation of the developing mammary gland. We have explored a role for Suppressor of Cytokine Signaling 1 (SOCS1) as a modulator of the prolactin response using mice deficient in SOCS1, which were rescued from neonatal death by deletion of the Interferon gamma (IFN gamma) gene. SOCS1(-/-)/IFN gamma(-/-) mice exhibited accelerated lobuloalveolar development in the mammary gland during late pregnancy and precocious lactation. Significantly, the lactogenic defect in prolactin receptor heterozygous females could be rescued by deletion of a single SOCS1 allele. These findings establish a role for SOCS1 as a negative regulator of prolactin signaling and suggest that SOCS1 is required for the prevention of lactation prior to parturition.

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