Viral Interferon Regulatory Factor 1 of Kaposi's Sarcoma-associated Herpesvirus Binds to P53 and Represses P53-dependent Transcription and Apoptosis

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2001 Jun 8

PMID 11390621

Citations 64

Authors

T Seo

J Park

D Lee

S G Hwang

J Choe

Affiliations

Soon will be listed here.

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is related to the development of Kaposi's sarcoma. Open reading frame K9 of KSHV encodes viral interferon regulatory factor 1 (vIRF1), which functions as a repressor of interferon- and IRF1-mediated signal transduction. In addition, vIRF1 acts as an oncogene to induce cellular transformation. Here we show that vIRF1 directly associates with the tumor suppressor p53 and represses its functions. The vIRF1 interaction domains of p53 are the DNA binding domain (amino acids [aa] 100 to 300) and the tetramerization domain (aa 300 to 393). p53 interacts with the central region (aa 152 to 360) of vIRF1. vIRF1 suppresses p53-dependent transcription and deregulates its apoptotic activity. These results suggest that vIRF1 may regulate cellular function by inhibiting p53.

Citing Articles

HIV-associated cancers and lymphoproliferative disorders caused by Kaposi sarcoma herpesvirus and Epstein-Barr virus.

Lurain K, Ramaswami R, Krug L, Whitby D, Ziegelbauer J, Wang H Clin Microbiol Rev. 2024; 37(3):e0002223.

PMID: 38899877 PMC: 11391709. DOI: 10.1128/cmr.00022-23.

Immune evasion strategy involving propionylation by the KSHV interferon regulatory factor 1 (vIRF1).

Shi J, Jia X, He Y, Ma X, Qi X, Li W PLoS Pathog. 2023; 19(4):e1011324.

PMID: 37023208 PMC: 10112802. DOI: 10.1371/journal.ppat.1011324.

Murine herpesvirus-68-related growth factors treatment correlates with decrease of p53 and HIF-1α protein levels.

Supolikova M, Novakova E, Donatova K, Olejnikova P, Labudova M Pathog Dis. 2023; 81.

PMID: 36997335 PMC: 10093997. DOI: 10.1093/femspd/ftad004.

A viral interferon regulatory factor degrades RNA-binding protein hnRNP Q1 to enhance aerobic glycolysis via recruiting E3 ubiquitin ligase KLHL3 and decaying GDPD1 mRNA.

Qi X, Yan Q, Shang Y, Zhao R, Ding X, Gao S Cell Death Differ. 2022; 29(11):2233-2246.

PMID: 35538151 PMC: 9613757. DOI: 10.1038/s41418-022-01011-1.

Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas.

Lakiotaki E, Kanakoglou D, Pampalou A, Karatrasoglou E, Piperi C, Korkolopoulou P Biomedicines. 2021; 9(11).

PMID: 34829872 PMC: 8615931. DOI: 10.3390/biomedicines9111642.

References

Lukac D, Kirshner J, Ganem D . Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J Virol. 1999; 73(11):9348-61. PMC: 112969. DOI: 10.1128/JVI.73.11.9348-9361.1999. View

Levine A . p53, the cellular gatekeeper for growth and division. Cell. 1997; 88(3):323-31. DOI: 10.1016/s0092-8674(00)81871-1. View

Rivas C, Thlick A, Parravicini C, Moore P, Chang Y . Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53. J Virol. 2000; 75(1):429-38. PMC: 113935. DOI: 10.1128/JVI.75.1.429-438.2001. View

Li M, Damania B, Alvarez X, Ogryzko V, Ozato K, Jung J . Inhibition of p300 histone acetyltransferase by viral interferon regulatory factor. Mol Cell Biol. 2000; 20(21):8254-63. PMC: 86434. DOI: 10.1128/MCB.20.21.8254-8263.2000. View

Parravicini C, Chandran B, Corbellino M, Berti E, Paulli M, Moore P . Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Am J Pathol. 2000; 156(3):743-9. PMC: 1876837. DOI: 10.1016/S0002-9440(10)64940-1. View

Seo T, Lee D, Lee B, Chung J, Choe J . Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) binds to, and inhibits transactivation of, CREB-binding protein. Biochem Biophys Res Commun. 2000; 270(1):23-7. DOI: 10.1006/bbrc.2000.2393. View

Park J, Seo T, Hwang S, Lee D, Gwack Y, Choe J . The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity. J Virol. 2000; 74(24):11977-82. PMC: 112483. DOI: 10.1128/jvi.74.24.11977-11982.2000. View

Graham F, Smiley J, Russell W, Nairn R . Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol. 1977; 36(1):59-74. DOI: 10.1099/0022-1317-36-1-59. View

Renne R, Zhong W, Herndier B, McGrath M, Abbey N, Kedes D . Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med. 1996; 2(3):342-6. DOI: 10.1038/nm0396-342. View

10.

Katano H, Sato Y, Kurata T, Mori S, Sata T . Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease. Virology. 2001; 269(2):335-44. DOI: 10.1006/viro.2000.0196. View

11.

Lee D, Lee B, Kim J, Kim D, Choe J . cAMP response element-binding protein-binding protein binds to human papillomavirus E2 protein and activates E2-dependent transcription. J Biol Chem. 2000; 275(10):7045-51. DOI: 10.1074/jbc.275.10.7045. View

12.

Burysek L, Yeow W, Lubyova B, Kellum M, Schafer S, Huang Y . Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300. J Virol. 1999; 73(9):7334-42. PMC: 104259. DOI: 10.1128/JVI.73.9.7334-7342.1999. View

13.

Kraiss S, Quaiser A, Oren M, Montenarh M . Oligomerization of oncoprotein p53. J Virol. 1988; 62(12):4737-44. PMC: 253589. DOI: 10.1128/JVI.62.12.4737-4744.1988. View

14.

Patel D, Huang S, Baglia L, McCance D . The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300. EMBO J. 1999; 18(18):5061-72. PMC: 1171577. DOI: 10.1093/emboj/18.18.5061. View

15.

Friborg Jr J, Kong W, Hottiger M, Nabel G . p53 inhibition by the LANA protein of KSHV protects against cell death. Nature. 2000; 402(6764):889-94. DOI: 10.1038/47266. View

16.

Pietenpol J, Tokino T, Thiagalingam S, El-Deiry W, Kinzler K, Vogelstein B . Sequence-specific transcriptional activation is essential for growth suppression by p53. Proc Natl Acad Sci U S A. 1994; 91(6):1998-2002. PMC: 43296. DOI: 10.1073/pnas.91.6.1998. View

17.

Soulier J, GROLLET L, Oksenhendler E, Cacoub P, Cazals-Hatem D, Babinet P . Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood. 1995; 86(4):1276-80. View

18.

Gao S, Boshoff C, Jayachandra S, Weiss R, Chang Y, Moore P . KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway. Oncogene. 1997; 15(16):1979-85. DOI: 10.1038/sj.onc.1201571. View

19.

Gorczyca W, Bigman K, Mittelman A, Ahmed T, Gong J, Melamed M . Induction of DNA strand breaks associated with apoptosis during treatment of leukemias. Leukemia. 1993; 7(5):659-70. View

20.

Li M, Lee H, Guo J, Neipel F, Fleckenstein B, Ozato K . Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor. J Virol. 1998; 72(7):5433-40. PMC: 110176. DOI: 10.1128/JVI.72.7.5433-5440.1998. View