Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2021 Nov 27

PMID 34829872

Citations 4

Authors

Eleftheria Lakiotaki

Dimitrios S Kanakoglou

Andromachi Pampalou

Eleni A Karatrasoglou

Christina Piperi

Penelope Korkolopoulou

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (circRNAs) are single-stranded RNAs generated from exons back-splicing from a single pre-mRNA, forming covalently closed loop structures which lack 5'-3'-polarity or polyadenylated tail. Ongoing research depicts that circRNAs play a pivotal role in tumorigenesis, tumor progression, metastatic potential and chemoresistance by regulating transcription, microRNA (miRNA) sponging, RNA-binding protein interactions, alternative splicing and to a lesser degree, protein coding. Sarcomas are rare malignant tumors stemming from mesenchymal cells. Due to their clinically insidious onset, they often present at advanced stage and their treatment may require aggressive chemotherapeutic or surgical options. This review is mainly focused on the regulatory functions of circRNAs on osteosarcoma progression and their potential role as biomarkers, an area which has prompted lately extensive research. The attributed oncogenic role of circRNAs on other mesenchymal tumors such as Kaposi Sarcoma (KS), Rhabdomyosarcoma (RMS) or Gastrointestinal Stromal Tumors (GISTs) is also described. The involvement of circRNAs on sarcoma oncogenesis and relevant emerging diagnostic, prognostic and therapeutic applications are expected to gain more research interest in the future.

Citing Articles

Circ_0027446 promotes malignant development of glioblastoma by interacting with miR-346 to up-regulate PGK1.

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The splicing factor proline and glutamine rich promotes the growth of osteosarcoma via the c-Myc signaling pathway.

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CircSHOC2 Knockdown Alleviates High Glucose-Induced Vascular Endothelial Cell Pyroptosis via Targeting miR-145/FOXO1 Axis In Vitro Condition.

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Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR.

Guo L, Jia L, Luo L, Xu X, Xiang Y, Ren Y Int J Mol Sci. 2022; 23(13).

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References

Agaram N, LaQuaglia M, Alaggio R, Zhang L, Fujisawa Y, Ladanyi M . MYOD1-mutant spindle cell and sclerosing rhabdomyosarcoma: an aggressive subtype irrespective of age. A reappraisal for molecular classification and risk stratification. Mod Pathol. 2018; 32(1):27-36. PMC: 6720105. DOI: 10.1038/s41379-018-0120-9. View

Bai Y, Li Y, Bai J, Zhang Y . Hsa_circ_0004674 promotes osteosarcoma doxorubicin resistance by regulating the miR-342-3p/FBN1 axis. J Orthop Surg Res. 2021; 16(1):510. PMC: 8371803. DOI: 10.1186/s13018-021-02631-y. View

Ivanov A, Memczak S, Wyler E, Torti F, Porath H, Orejuela M . Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Cell Rep. 2015; 10(2):170-7. DOI: 10.1016/j.celrep.2014.12.019. View

Lopes L, Bacchi C . Imatinib treatment for gastrointestinal stromal tumour (GIST). J Cell Mol Med. 2009; 14(1-2):42-50. PMC: 3837608. DOI: 10.1111/j.1582-4934.2009.00983.x. View

Zhang R, Xu J, Zhao J, Wang X . Silencing of hsa_circ_0007534 suppresses proliferation and induces apoptosis in colorectal cancer cells. Eur Rev Med Pharmacol Sci. 2018; 22(1):118-126. DOI: 10.26355/eurrev_201801_14108. View

Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S . Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998; 279(5350):577-80. DOI: 10.1126/science.279.5350.577. View

Yang Y, Kong F, Cai Y, Ding Q, Tang B . Enhanced CDR1as Promotes the Development of Bladder Urothelial Carcinoma. Clin Lab. 2020; 66(7). DOI: 10.7754/Clin.Lab.2019.191213. View

Gu H, Cheng X, Xu J, Zhou K, Bian C, Chen G . Circular RNA circFAT1(e2) Promotes Osteosarcoma Progression and Metastasis by Sponging miR-181b and Regulating HK2 Expression. Biomed Res Int. 2020; 2020:3589871. PMC: 7378629. DOI: 10.1155/2020/3589871. View

Zhang H, Meng F, Dong S . circSMARCA5 Promoted Osteosarcoma Cell Proliferation, Adhesion, Migration, and Invasion through a Competing Endogenous RNA Network. Biomed Res Int. 2020; 2020:2539150. PMC: 7537690. DOI: 10.1155/2020/2539150. View

10.

Liu Y, Dong Y, Zhao L, Su L, Luo J . Circular RNA‑MTO1 suppresses breast cancer cell viability and reverses monastrol resistance through regulating the TRAF4/Eg5 axis. Int J Oncol. 2018; 53(4):1752-1762. DOI: 10.3892/ijo.2018.4485. View

11.

Fang J, Hong H, Xue X, Zhu X, Jiang L, Qin M . A novel circular RNA, circFAT1(e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus. Cancer Lett. 2018; 442:222-232. DOI: 10.1016/j.canlet.2018.10.040. View

12.

He Y, Mingyan E, Wang C, Liu G, Shi M, Liu S . CircVRK1 regulates tumor progression and radioresistance in esophageal squamous cell carcinoma by regulating miR-624-3p/PTEN/PI3K/AKT signaling pathway. Int J Biol Macromol. 2018; 125:116-123. DOI: 10.1016/j.ijbiomac.2018.11.273. View

13.

Huang C, Liang D, Tatomer D, Wilusz J . A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs. Genes Dev. 2018; 32(9-10):639-644. PMC: 6004072. DOI: 10.1101/gad.314856.118. View

14.

Liu Y, Jiang Y, Xu L, Qu C, Zhang L, Xiao X . circ-NRIP1 Promotes Glycolysis and Tumor Progression by Regulating miR-186-5p/MYH9 Axis in Gastric Cancer. Cancer Manag Res. 2020; 12:5945-5956. PMC: 7381786. DOI: 10.2147/CMAR.S245941. View

15.

Li J, Sun D, Pu W, Wang J, Peng Y . Circular RNAs in Cancer: Biogenesis, Function, and Clinical Significance. Trends Cancer. 2020; 6(4):319-336. DOI: 10.1016/j.trecan.2020.01.012. View

16.

Li X, Sun X, Xu H, Pan H, Liu Y, He L . Circ_ORC2 enhances the regulatory effect of miR-19a on its target gene PTEN to affect osteosarcoma cell growth. Biochem Biophys Res Commun. 2019; 514(4):1172-1178. DOI: 10.1016/j.bbrc.2019.04.188. View

17.

Ashwal-Fluss R, Meyer M, Pamudurti N, Ivanov A, Bartok O, Hanan M . circRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 2014; 56(1):55-66. DOI: 10.1016/j.molcel.2014.08.019. View

18.

Wu X, Yan L, Liu Y, Shang L . Circ_0000527 promotes osteosarcoma cell progression through modulating miR-646/ARL2 axis. Aging (Albany NY). 2021; 13(4):6091-6102. PMC: 7950279. DOI: 10.18632/aging.202602. View

19.

Li Z, Huang C, Bao C, Chen L, Lin M, Wang X . Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 2015; 22(3):256-64. DOI: 10.1038/nsmb.2959. View

20.

Yang L, Wang J, Fan Y, Yu K, Jiao B, Su X . Hsa_circ_0046264 up-regulated BRCA2 to suppress lung cancer through targeting hsa-miR-1245. Respir Res. 2018; 19(1):115. PMC: 5996480. DOI: 10.1186/s12931-018-0819-7. View