Kaposi's Sarcoma-associated Herpesvirus Viral Interferon Regulatory Factor

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1998 Jun 17

PMID 9620998

Citations 63

Authors

M Li

H Lee

J Guo

F Neipel

B Fleckenstein

K Ozato

J U Jung

Affiliations

Soon will be listed here.

Abstract

Interferons (IFNs) are a family of multifunctional cytokines with antiviral activities. The K9 open reading frame of Kaposi's sarcoma-associated herpesvirus (KSHV) exhibits significant homology with cellular IFN regulatory factors (IRFs). We have investigated the functional consequence of K9 expression in IFN-mediated signal transduction. Expression of K9 dramatically repressed transcriptional activation induced by IFN-alpha, -beta, and -gamma. Further, it induced transformation of NIH 3T3 cells, resulting in morphologic changes, focus formation, and growth in reduced-serum conditions. The expression of antisense K9 in KSHV-infected BCBL-1 cells consistently increased IFN-mediated transcriptional activation but drastically decreased the expression of certain KSHV genes. Thus, the K9 gene of KSHV encodes the first virus-encoded IRF (v-IRF) which functions as a repressor for cellular IFN-mediated signal transduction. In addition, v-IRF likely plays an important role in regulating KSHV gene expression. These results suggest that KSHV employs an unique mechanism to antagonize IFN-mediated antiviral activity by harboring a functional v-IRF.

Citing Articles

The Role of vIL-6 in KSHV-Mediated Immune Evasion and Tumorigenesis.

Komaki S, Inagaki T, Kumar A, Izumiya Y Viruses. 2025; 16(12.

PMID: 39772207 PMC: 11680145. DOI: 10.3390/v16121900.

Mapping herpesvirus-driven impacts on the cellular milieu and transcriptional profile of Kaposi sarcoma in patient-derived mouse models.

Li X, Ohler Z, Day A, Bassel L, Grosskopf A, Afsari B bioRxiv. 2024; .

PMID: 39386738 PMC: 11463583. DOI: 10.1101/2024.09.27.615429.

Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2.

Yang Z, Xiang Q, Nicholas J PLoS Pathog. 2023; 19(11):e1011806.

PMID: 37983265 PMC: 10695398. DOI: 10.1371/journal.ppat.1011806.

Murine herpesvirus-68-related growth factors treatment correlates with decrease of p53 and HIF-1α protein levels.

Supolikova M, Novakova E, Donatova K, Olejnikova P, Labudova M Pathog Dis. 2023; 81.

PMID: 36997335 PMC: 10093997. DOI: 10.1093/femspd/ftad004.

STAT and Janus kinase targeting by human herpesvirus 8 interferon regulatory factor in the suppression of type-I interferon signaling.

Xiang Q, Yang Z, Nicholas J PLoS Pathog. 2022; 18(7):e1010676.

PMID: 35776779 PMC: 9307175. DOI: 10.1371/journal.ppat.1010676.

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