Certified Professionals: CD4(+)CD25(+) Suppressor T Cells

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2001 Jun 8

PMID 11390442

Citations 136

Authors

E M Shevach

Affiliations

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Citing Articles

Immune Cell Plasticity Allows for Resetting of Phenotype From Effector to Regulator With Combined Inhibition of Notch/eIF5A Pathways.

Imam S, Dar P, Aziz S, Zahid Z, Sarwar H, Karim T Front Cell Dev Biol. 2021; 9:777805.

PMID: 34881246 PMC: 8645838. DOI: 10.3389/fcell.2021.777805.

Searching for Peptide Inhibitors of T Regulatory Cell Activity by Targeting Specific Domains of FOXP3 Transcription Factor.

Lozano T, Casares N, Martil-Otal C, Anega B, Gorraiz M, Parker J Biomedicines. 2021; 9(2).

PMID: 33671179 PMC: 7922534. DOI: 10.3390/biomedicines9020197.

Interleukin 35 Regulatory B Cells.

Choi J, Egwuagu C J Mol Biol. 2020; 433(1):166607.

PMID: 32755620 PMC: 7779660. DOI: 10.1016/j.jmb.2020.07.019.

The Role of IL-33 in Experimental Heart Transplantation.

Chen J, He Y, Xie Z, Wei Y, Duan L Cardiol Res Pract. 2020; 2020:6108362.

PMID: 32257426 PMC: 7106886. DOI: 10.1155/2020/6108362.

The role of regulatory T cells in allergic rhinitis and their correlation with IL-10, IL-17 and neopterin levels in serum and nasal lavage fluid.

Erkan K, Bozkurt M, Artac H, Ozdemir H, Unlu A, Korucu E Eur Arch Otorhinolaryngol. 2020; 277(4):1109-1114.

PMID: 31993765 DOI: 10.1007/s00405-020-05811-4.

References

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Thornton A, Shevach E . CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med. 1998; 188(2):287-96. PMC: 2212461. DOI: 10.1084/jem.188.2.287. View

Levings M, Sangregorio R, Roncarolo M . Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med. 2001; 193(11):1295-302. PMC: 2193376. DOI: 10.1084/jem.193.11.1295. View

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Stephens L, Mason D . CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations. J Immunol. 2000; 165(6):3105-10. DOI: 10.4049/jimmunol.165.6.3105. View

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Taylor P, Panoskaltsis-Mortari A, Noelle R, Blazar B . Analysis of the requirements for the induction of CD4+ T cell alloantigen hyporesponsiveness by ex vivo anti-CD40 ligand antibody. J Immunol. 2000; 164(2):612-22. DOI: 10.4049/jimmunol.164.2.612. View

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Stephens L, Mottet C, Mason D, Powrie F . Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur J Immunol. 2001; 31(4):1247-54. DOI: 10.1002/1521-4141(200104)31:4<1247::aid-immu1247>3.0.co;2-m. View

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Read S, Mauze S, Asseman C, Bean A, COFFMAN R, Powrie F . CD38+ CD45RB(low) CD4+ T cells: a population of T cells with immune regulatory activities in vitro. Eur J Immunol. 1998; 28(11):3435-47. DOI: 10.1002/(SICI)1521-4141(199811)28:11<3435::AID-IMMU3435>3.0.CO;2-P. View

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PAPIERNIK M, de Moraes M, Pontoux C, Vasseur F, Penit C . Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int Immunol. 1998; 10(4):371-8. DOI: 10.1093/intimm/10.4.371. View

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Itoh M, Takahashi T, Sakaguchi N, KUNIYASU Y, Shimizu J, Otsuka F . Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol. 1999; 162(9):5317-26. View

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Taams L, Smith J, Rustin M, Salmon M, Poulter L, Akbar A . Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population. Eur J Immunol. 2001; 31(4):1122-31. DOI: 10.1002/1521-4141(200104)31:4<1122::aid-immu1122>3.0.co;2-p. View

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Hara M, Kingsley C, Niimi M, Read S, Turvey S, Bushell A . IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol. 2001; 166(6):3789-96. DOI: 10.4049/jimmunol.166.6.3789. View

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Shevach E . Regulatory T cells in autoimmmunity*. Annu Rev Immunol. 2000; 18:423-49. DOI: 10.1146/annurev.immunol.18.1.423. View

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Thornton A, Shevach E . Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol. 1999; 164(1):183-90. DOI: 10.4049/jimmunol.164.1.183. View

20.

Taylor P, Noelle R, Blazar B . CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med. 2001; 193(11):1311-8. PMC: 2193378. DOI: 10.1084/jem.193.11.1311. View