Can VEGF Reverse Diabetic Neuropathy in Human Subjects?

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2001 May 26

PMID 11375408

Citations 22

Authors

A Veves

G L King

Affiliations

Soon will be listed here.

Citing Articles

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Insulin enhances neurite extension and myelination of diabetic neuropathy neurons.

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References

Aiello L, Avery R, Arrigg P, Keyt B, Jampel H, Shah S . Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994; 331(22):1480-7. DOI: 10.1056/NEJM199412013312203. View

Schratzberger P, Schratzberger G, Silver M, Curry C, Kearney M, Magner M . Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. Nat Med. 2000; 6(4):405-13. DOI: 10.1038/74664. View

Sima A, Bouchier M, Christensen H . Axonal atrophy in sensory nerves of the diabetic BB-Wistar rat: a possible early correlate of human diabetic neuropathy. Ann Neurol. 1983; 13(3):264-72. DOI: 10.1002/ana.410130307. View

Pham H, Armstrong D, Harvey C, Harkless L, Giurini J, Veves A . Screening techniques to identify people at high risk for diabetic foot ulceration: a prospective multicenter trial. Diabetes Care. 2000; 23(5):606-11. DOI: 10.2337/diacare.23.5.606. View

Tesfaye S, Malik R, Ward J . Vascular factors in diabetic neuropathy. Diabetologia. 1994; 37(9):847-54. DOI: 10.1007/BF00400938. View

Cameron N, Cotter M . Metabolic and vascular factors in the pathogenesis of diabetic neuropathy. Diabetes. 1997; 46 Suppl 2:S31-7. DOI: 10.2337/diab.46.2.s31. View

Duh E, Aiello L . Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox. Diabetes. 1999; 48(10):1899-906. DOI: 10.2337/diabetes.48.10.1899. View

Apfel S, Schwartz S, Adornato B, Freeman R, Biton V, Rendell M . Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial. rhNGF Clinical Investigator Group. JAMA. 2000; 284(17):2215-21. DOI: 10.1001/jama.284.17.2215. View

Cameron N, Cotter M, Low P . Nerve blood flow in early experimental diabetes in rats: relation to conduction deficits. Am J Physiol. 1991; 261(1 Pt 1):E1-8. DOI: 10.1152/ajpendo.1991.261.1.E1. View

10.

Theriault M, Dort J, Sutherland G, Zochodne D . Local human sural nerve blood flow in diabetic and other polyneuropathies. Brain. 1997; 120 ( Pt 7):1131-8. DOI: 10.1093/brain/120.7.1131. View

11.

Vincent K, Shyu K, Luo Y, Magner M, Tio R, Jiang C . Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor. Circulation. 2000; 102(18):2255-61. DOI: 10.1161/01.cir.102.18.2255. View

12.

Xia P, Aiello L, Ishii H, Jiang Z, Park D, Robinson G . Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest. 1996; 98(9):2018-26. PMC: 507645. DOI: 10.1172/JCI119006. View

13.

FAGERBERG S . Diabetic neuropathy: a clinical and histological study on the significance of vascular affections. Acta Med Scand Suppl. 1959; 345:1-97. View

14.

Samii A, Unger J, Lange W . Vascular endothelial growth factor expression in peripheral nerves and dorsal root ganglia in diabetic neuropathy in rats. Neurosci Lett. 1999; 262(3):159-62. DOI: 10.1016/s0304-3940(99)00064-6. View

15.

Shweiki D, Itin A, Soffer D, Keshet E . Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 1992; 359(6398):843-5. DOI: 10.1038/359843a0. View

16.

Isner J . Tissue responses to ischemia: local and remote responses for preserving perfusion of ischemic muscle. J Clin Invest. 2000; 106(5):615-9. PMC: 381295. DOI: 10.1172/JCI10961. View

17.

Stevens E, Carrington A, Tomlinson D . Nerve ischaemia in diabetic rats: time-course of development, effect of insulin treatment plus comparison of streptozotocin and BB models. Diabetologia. 1994; 37(1):43-8. DOI: 10.1007/BF00428776. View

18.

Nakamura J, Kato K, Hamada Y, Nakayama M, Chaya S, Nakashima E . A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats. Diabetes. 1999; 48(10):2090-5. DOI: 10.2337/diabetes.48.10.2090. View

19.

Schratzberger P, Walter D, Rittig K, Bahlmann F, Pola R, Curry C . Reversal of experimental diabetic neuropathy by VEGF gene transfer. J Clin Invest. 2001; 107(9):1083-92. PMC: 209283. DOI: 10.1172/JCI12188. View

20.

Feldman E, Stevens M, Greene D . Pathogenesis of diabetic neuropathy. Clin Neurosci. 1997; 4(6):365-70. View