Bumetanide: A Preliminary Report of Its Pharmacological Properties and Therapeutic Efficacy in Oedema

Overview

Journal Drugs

Specialty Pharmacology

Date 1975 Jan 1

PMID 1126304

Citations 5

Authors

R N Brogden

T M Speight

G S Avery

Affiliations

Soon will be listed here.

Abstract

Bumetanide2 is a new diuretic with a rapid onset and short duration of action. It is advocated for the treatment of oedema of cardiac origin; that associated with cirrhosis of the liver and renal diseases, including the nephrotic syndrome oedema of pregnancy and in pulmonary oedema. Bumetanide produces a pattern of water and electrolyte excretion closely resembling that of frusemide although it differs structurally from frusemide and other diuretics. 1 mg of bumetanide produces a diuretic effect similar to that evoked by 40 to 60 mg of frusemide. Short-and long-term studies in oedema of varying aetiology have shown bumetanide to be an effective diuretic. Because it is chemically different from existing diuretics, bumetanide may be helpful in oedema resistant to other drugs. It is well tolerated, but like other natriuretics it causes hypericaemia and may cause hypokalaemia during long-term administration.

Citing Articles

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Immediate effects of bumetanide on systemic haemodynamics and left ventricular volume in acute and chronic heart failure.

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References

Asbury M, Gatenby P, OSullivan S, Bourke E . Bumetanide: potent new "loop" diuretic. Br Med J. 1972; 1(5794):211-3. PMC: 1789187. DOI: 10.1136/bmj.1.5794.211. View

Sigurd B . [Supra-additive natriuretic effect of theophyllamine in patients with chronic congestive heart failure during long-term therapy with bumethanide]. Ugeskr Laeger. 1973; 135(41):2218-22. View

OLESEN K, Sigurd B, Steiness E, Leth A . Bumetanide, a new potent diuretic. A clinical evaluation in congestive heart failure. Acta Med Scand. 1973; 193(1-2):119-31. View

Davies D, Lant A, Millard N, Smith A, Ward J, WILSON G . Renal action, therapeutic use, and pharmacokinetics of the diuretic bumetanide. Clin Pharmacol Ther. 1974; 15(2):141-55. DOI: 10.1002/cpt1974152141. View

Ring-Larsen H . Bumetanide in the treatment of hepatic ascites. A short and long-term study. Acta Med Scand. 1974; 195(5):411-4. DOI: 10.1111/j.0954-6820.1974.tb08161.x. View

ROBSON A, Kerr D, Ashcroft R, Teasdale G . THE DIURETIC RESPONSE TO FRUSEMIDE. Lancet. 1964; 2(7369):1085-8. DOI: 10.1016/s0140-6736(64)92608-x. View

Henning R, LUNDVALL O . Evaluation in man of bumetanide, a new diuretic agent. Eur J Clin Pharmacol. 1973; 6(4):224-7. DOI: 10.1007/BF00644736. View

Sigurd B, Hesse B, Valentin N . Bumetanide: a new potent diuretic. The effects of a single intravenous dose in patients with congestive heart failure. Dan Med Bull. 1974; 21(2):63-7. View

Reumert T, ZACHARIAE L . Continued investigations into the effect of diuretics upon oedema of the hand following operation for Dupuytren's contracture: Bumetanide Leo. Acta Orthop Scand. 1973; 44(4):410-6. DOI: 10.3109/17453677308989076. View

10.

Ostergaard E, Magnussen M, Nielsen C, EILERTSEN E, Frey H . Pharmacological properties of 3-n-butylamino-4-phenoxy-5-sulfamylbenzoic acid (Bumetanide), a new potent diuretic. Arzneimittelforschung. 1972; 22(1):66-72. View

11.

FEIT P, ROHOLT K, Sorensen H . GLC determination and urinary recovery of bumetanide in healthy volunteers. J Pharm Sci. 1973; 62(3):375-9. DOI: 10.1002/jps.2600620304. View

12.

Pines A, Sreedharan K, Nandi A, Marsh B . A clinical assessment of bumetanide in patients not responding to other diuretics. Br J Clin Pract. 1974; 28(9):311-13. View

13.

ZACHARIAE L, Clemmensen T, OLESEN E, Ulfeldt M . The effect of diuretic (Centyl, Leo) on the oedema of the hand following surgical treatment of Dupuytren's contracture. Acta Orthop Scand. 1970; 41(4):411-8. DOI: 10.3109/17453677008991528. View

14.

Hofstetter A . Bumetanide, a new diuretic. Int Urol Nephrol. 1974; 6(1):35-42. DOI: 10.1007/BF02086910. View

15.

SUKI W, RECTOR Jr F, SELDIN D . THE SITE OF ACTION OF FUROSEMIDE AND OTHER SULFONAMIDE DIURETICS IN THE DOG. J Clin Invest. 1965; 44:1458-69. PMC: 292627. DOI: 10.1172/JCI105252. View

16.

ANDERTON J, Kincaid-Smith P . Diuretics. I. Physiological and pharmacological considerations. Drugs. 1971; 1(1):54-81. DOI: 10.2165/00003495-197101010-00004. View

17.

Karlander S, Henning R, LUNDVALL O . Renal effects of bumetanide, a new saluretic agent. Eur J Clin Pharmacol. 1973; 6(4):220-3. DOI: 10.1007/BF00644735. View

18.

FEIT P . Aminobenzoic acid diuretics. 2. 4-Substituted-3-amino-5-sulfamylbenzoic acid derivatives. J Med Chem. 1971; 14(5):432-9. DOI: 10.1021/jm00287a014. View

19.

Bourke E, Asbury M, OSullivan S, Gatenby P . The sites of action of bumetanide in man. Eur J Pharmacol. 1973; 23(3):283-9. DOI: 10.1016/0014-2999(73)90096-4. View

20.

Bollerup A, Hesse B, Sigurd B . Changes of glomerular filtration rate and renal plasma flow following intravenous bumetanide in organic heart disease. Acta Pharmacol Toxicol (Copenh). 1974; 34(5):305-11. DOI: 10.1111/j.1600-0773.1974.tb03527.x. View