R N Brogden
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Explore the profile of R N Brogden including associated specialties, affiliations and a list of published articles.
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Articles
251
Citations
5208
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Recent Articles
1.
Brogden R, Wiseman L
Drugs
. 1998 Nov;
56(4):709-23.
PMID: 9806112
The topoisomerase I inhibitor topotecan has shown antitumour activity against a variety of tumour types in vitro and in vivo. Topotecan in combination with drugs that induce DNA damage generally...
2.
Brogden R, Goa K, Coukell A
Drugs
. 1998 Oct;
56(3):365-83.
PMID: 9777313
Unlabelled: Formulation of amphotericin B with sodium cholesteryl sulphate alters the pharmacokinetic properties of the drug, particularly reducing its distribution to the kidneys. The antifungal activity in vitro of amphotericin...
3.
Brogden R, Wiseman L
Drugs
. 1998 Jun;
55(6):845-60.
PMID: 9617599
Unlabelled: Moexipril is a prodrug which is hydrolysed after oral administration to its active metabolite moexiprilat, an inhibitor of the angiotensin converting enzyme (ACE). Once daily administration of moexipril 7.5...
4.
Foster R, Brogden R, Benfield P
Drugs
. 1998 May;
55(5):705-11; discussion 712.
PMID: 9585866
Tazarotene is a topical retinoid that appears to exert its effects via retinoic acid receptors. It normalises differentiation and proliferation of keratinocytes and has an anti-inflammatory effect. Topical tazarotene 0.05%...
5.
Coukell A, Brogden R
Drugs
. 1998 Apr;
55(4):585-612.
PMID: 9561346
Incorporation of amphotericin B into small unilamellar liposomes (AmBisome) alters the pharmacokinetic properties of the drug, but allows it to retain significant in vitro and in vivo activity against fungal...
6.
Wiseman L, Brogden R
Drugs Aging
. 1998 Apr;
12(3):243-8; discussion 249-50.
PMID: 9534023
Propionyl-L-carnitine stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activity. The free radical scavenging activity of the drug may also be beneficial....
7.
Bartow R, Brogden R
Drugs
. 1998 Mar;
55(2):303-22.
PMID: 9506248
Formoterol, a selective beta 2-adrenoceptor agonist, produces effective dose-proportional bronchodilation, which persists for up to 12 hours, in patients with reversible obstructive respiratory disease. Bronchodilation is significant within minutes of...
8.
Adkins J, Brogden R
Drugs
. 1998 Feb;
55(1):121-44.
PMID: 9463793
Zafirlukast is a competitive and selective leukotriene receptor antagonist indicated for the prophylaxis and treatment of chronic asthma. The rationale for the development of leukotriene antagonists was based on in...
9.
Brogden R, Markham A
Drugs
. 1997 Nov;
54(5):774-93.
PMID: 9360062
Mibefradil belongs to a new class of calcium antagonists, the tetralol derivatives. It selectively blocks T-type calcium channels in contrast to other calcium antagonists which block only L-type channels. Mibefradil...
10.
Brogden R, Markham A
Drugs
. 1997 Oct;
54(4):634-50.
PMID: 9339965
Fenoldopam is a dopamine agonist that causes peripheral vasodilation via stimulation of dopamine 1 (D1) receptors. The efficacy of an intravenous infusion of fenoldopam in decreasing blood pressure in patients...