Heteroaryl and Cycloalkyl Sulfonamide Hydroxamic Acid Inhibitors of Matrix Metalloproteinases

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2001 Feb 24

PMID 11206468

Citations 3

Authors

J I Levin

Y Gu

F C Nelson

A Zask

J F DiJoseph

M A Sharr

A Sung

G Jin

R Cowling

P Chanda

S Cosmi

C L Hsiao

W Edris

J Wilhelm

L M Killar

J S Skotnicki

Affiliations

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Abstract

Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro.

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