Secret Sharers in the Immune System: a Novel RNA Editing Activity Links Switch Recombination and Somatic Hypermutation
Overview
Overview
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
A new mechanism for regulation in the immune system has been identified: a cytidine deaminase is critical for both class switch recombination and somatic hypermutation, revealing an unanticipated link between these two processes.
References
1.
Muto T, Muramatsu M, Taniwaki M, Kinoshita K, Honjo T
. Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene. Genomics. 2000; 68(1):85-8.
DOI: 10.1006/geno.2000.6268.
View
2.
Oettinger M
. V(D)J recombination: on the cutting edge. Curr Opin Cell Biol. 1999; 11(3):325-9.
DOI: 10.1016/S0955-0674(99)80044-1.
View
3.
Revy P, Muto T, Levy Y, Geissmann F, Plebani A, Sanal O
. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell. 2000; 102(5):565-75.
DOI: 10.1016/s0092-8674(00)00079-9.
View
4.
Dunnick W, Hertz G, Scappino L, Gritzmacher C
. DNA sequences at immunoglobulin switch region recombination sites. Nucleic Acids Res. 1993; 21(3):365-72.
PMC: 309126.
DOI: 10.1093/nar/21.3.365.
View
5.
Scott J
. A place in the world for RNA editing. Cell. 1995; 81(6):833-6.
DOI: 10.1016/0092-8674(95)90002-0.
View