The Expression of GABA(A) Receptor Subunits in the Substantia Nigra is Developmentally Regulated and Region-specific

Overview

Journal Ital J Neurol Sci

Specialty Neurology

Date 2000 Aug 10

PMID 10933458

Citations 11

Authors

J Veliskova

H Kubova

L K Friedman

R Wu

E F Sperber

R S Zukin

S L Moshe

Affiliations

Soon will be listed here.

Abstract

The substantia nigra pars reticulata (SNR) controls the spread of seizures. GABA(A)ergic drug (agonist or antagonist) infusions into the SNR have age-specific and site-specific effects on flurothyl-induced seizures. Developmental and cell-specific regulation of GABA(A) receptor subunit expression may be responsible for these specific effects. To test this hypothesis, in situ hybridization was used to examine regional expression of alpha1 and gamma2L GABA(A) receptor subunit mRNAs in the SNR during development. Distinct temporal and spatial patterns of expression were observed. In rats at postnatal days (PN) 21-60, fewer neurons were labeled with probes directed to alpha1 and gamma2L subunits in SNRanterior compared with SNRposterior. In addition, neurons in SNRanterior contained higher amounts of hybridization grains than in SNRposterior. In PN 15 rats, the labeling of neurons was relatively diffuse throughout the anterior and posterior SNR regions with moderate amounts of hybridization grains for both subunits. The finding of age-related differential distribution of alpha1 and gamma2L subunit mRNAs in the SNR suggests that GABA(A) receptor heterogeneity may play a role in the age-specific and site-specific effects of GABA(A)ergic agents on seizures in the SNR.

Citing Articles

Not Part of the Temporal Lobe, but Still of Importance? Substantia Nigra and Subthalamic Nucleus in Epilepsy.

Broer S Front Syst Neurosci. 2020; 14:581826.

PMID: 33381016 PMC: 7768985. DOI: 10.3389/fnsys.2020.581826.

The role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy.

Akman O, Gulcebi M, Carcak N, Ketenci Ozatman S, Eryigit T, Moshe S Epilepsia. 2015; 56(11):1793-802.

PMID: 26471261 PMC: 4626362. DOI: 10.1111/epi.13204.

Chudomel O, Hasson H, Bojar M, Moshe S, Galanopoulou A Neurochem Res. 2015; 40(4):747-57.

PMID: 25645446 PMC: 4380811. DOI: 10.1007/s11064-015-1523-3.

Sex dimorphism in seizure-controlling networks.

Giorgi F, Galanopoulou A, Moshe S Neurobiol Dis. 2014; 72 Pt B:144-52.

PMID: 24851800 PMC: 4239199. DOI: 10.1016/j.nbd.2014.05.010.

Age- and gender-related differences in GABAA receptor-mediated postsynaptic currents in GABAergic neurons of the substantia nigra reticulata in the rat.

Chudomel O, Herman H, Nair K, Moshe S, Galanopoulou A Neuroscience. 2009; 163(1):155-67.

PMID: 19531372 PMC: 2729356. DOI: 10.1016/j.neuroscience.2009.06.025.

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