L K Friedman
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Explore the profile of L K Friedman including associated specialties, affiliations and a list of published articles.
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30
Citations
337
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Recent Articles
1.
Friedman L, Kahen B, Velisek L, Veliskova J
Brain Res
. 2022 Mar;
1783:147849.
PMID: 35231419
Chronic subconvulsive activity in early life leads to sex-related autistic-like deficits in handling, object recognition, and social performance in pre-pubertal rats. Since autism and epilepsy are common neurodevelopmental disorders with...
2.
Friedman L, Peng H, Zeman R
Exp Neurol
. 2021 Aug;
346:113844.
PMID: 34428457
Despite the high incidence of traumatic brain injury (TBI), there is no universal treatment to safely treat patients. Blunt brain injuries destroy primary neural tissue that results in impaired perfusion,...
3.
Friedman L, Kahen B
Behav Brain Res
. 2019 Aug;
374:112046.
PMID: 31376443
The diagnosis of autism spectrum disorder (ASD) varies from very mild to severe social and cognitive impairments. We hypothesized that epigenetic subconvulsive activity in early postnatal life may contribute to...
4.
Friedman L, Osei-Tutu N, Zhang B
Mol Cell Neurosci
. 2019 May;
98:54-69.
PMID: 31085233
Early life traumas lead to neuroprotection by preconditioning mechanisms. To determine which genes and pathways are most likely involved in specific adaptive effects, immature hippocampal cultures were exposed to a...
5.
Friedman L, Sharma A, Corcia M, Webster T, Qazi L, Simsovits D, et al.
Int J Dev Neurosci
. 2016 Aug;
54:6-21.
PMID: 27530811
The present study examined whether a single or multiple episode(s) of status epilepticus induced with kainic acid (KA) during the first 3 weeks of postnatal (P) development would aberrantly stimulate...
6.
Friedman L, Slomko A, Wongvravit J, Naseer Z, Hu S, Wan W, et al.
J Epilepsy Res
. 2016 Jan;
5(2):46-59.
PMID: 26819936
Background And Purpose: The efficacy of retigabine (RGB), a positive allosteric modulator of K+ channels indicated for adjunct treatment of partial seizures, was studied in two adult models of kainic...
7.
Slomko A, Naseer Z, Ali S, Wongvravit J, Friedman L
Epilepsy Behav
. 2014 Jul;
37:123-32.
PMID: 25016241
In adult rats, intraperitoneal injection of kainate (KA) results in sustained status epilepticus and persistent behavioral comorbidities such as hyperexcitability, anxiety, and altered response to environmental cues. Intrahippocampal KA also...
8.
Friedman L, Mancuso J, Patel A, Kudur V, Leheste J, Iacobas S, et al.
Eur J Neurosci
. 2013 Apr;
38(1):2139-52.
PMID: 23551718
Injury of the CA1 subregion induced by a single injection of kainic acid (1 × KA) in juvenile animals (P20) is attenuated in animals with two prior sustained neonatal seizures...
9.
Friedman L, Goldstein B, Rafiuddin A, Roblejo P, Friedman S
Neuroscience
. 2012 Nov;
230:39-49.
PMID: 23159308
In adult rats, trans-resveratrol attenuates kainic acid (KA)-induced convulsions and the associated hippocampal neurotoxicity. Increased neuronal survival was correlated with reduced lipid peroxidation. Since free radical generation after KA is...
10.
Rudenko V, Rafiuddin A, Leheste J, Friedman L
Pharmacol Biochem Behav
. 2011 Oct;
100(3):474-84.
PMID: 22019959
Cannabinoids have anti-convulsant effects in both in vivo and in vitro models of status epilepticus. Since the development of spontaneous seizures and neuronal vulnerability are age-dependent, we hypothesized that the...