Plants and Animals Share Functionally Common Bacterial Virulence Factors

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2000 Aug 2

PMID 10922040

Citations 160

Authors

L G Rahme

F M Ausubel

H Cao

E Drenkard

B C Goumnerov

G W Lau

J Plotnikova

M W Tan

J Tsongalis

C L Walendziewicz

R G Tompkins

Affiliations

Soon will be listed here.

Abstract

By exploiting the ability of Pseudomonas aeruginosa to infect a variety of vertebrate and nonvertebrate hosts, we have developed model systems that use plants and nematodes as adjuncts to mammalian models to help elucidate the molecular basis of P. aeruginosa pathogenesis. Our studies reveal a remarkable degree of conservation in the virulence mechanisms used by P. aeruginosa to infect hosts of divergent evolutionary origins.

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