Novel Nikkomycin Analogues: Inhibitors of the Fungal Cell Wall Biosynthesis Enzyme Chitin Synthase

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2000 Jul 11

PMID 10888330

Citations 4

Authors

K Obi

J Uda

K Iwase

O SUGIMOTO

H Ebisu

A Matsuda

Affiliations

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Abstract

A series of novel nikkomycin analogue inhibitors of the chitin synthase of fungal cell wall was synthesized and evaluated for their inhibitory activities. Among them, the compound having a phenanthrene group at the terminal amino acid was found to possess strong anti-chitin synthase activity.

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