B-lymphocyte Alloantigens in Caucasians

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1976 Apr 1

PMID 1082922

Citations 7

Authors

A Ting

M R Mickey

P I Terasaki

Affiliations

Soon will be listed here.

Abstract

Human B lymphocytes have been shown to have at least five polymorphic specificities defined by 32 antisera. The antisera were produced by absorption with pooled platelets to remove HLA activity and were selected out of over 400 tested sera. The sera that defined the five specificities had high correlation coefficients within a group (generally in the range of 0.6-0.9). As shown by the fit in the Hardy-Weinberg equilibrium, the five specificities appear to be determined by alleles at one genetic locus. No association between these specificities and HLA was noted.

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References

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Mann D, ABELSON L, Harris S, Amos D . Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera. J Exp Med. 1975; 142(1):84-9. PMC: 2189880. DOI: 10.1084/jem.142.1.84. View