Multiple Sclerosis in the Orkney and Shetland Islands. III: Histocompatibility Determinants

Overview

Journal J Epidemiol Community Health

Specialty Health Services

Date 1980 Dec 1

PMID 6972433

Citations 11

Authors

D C POSKANZER

P I Terasaki

L B Prenney

J L Sheridan

M S Park

Affiliations

Soon will be listed here.

Abstract

Histocompatibility testing was performed in 48 multiple sclerosis patients and two carefully matched control groups in Orkney Islands, an area of high multiple sclerosis prevalence. The frequency of HLA-A3, HLA-B7, and DW2 was comparable in patients and controls. However, HLA-B7 was significantly more common in female patients compared with male patients. A B-cell alloantigen (B-cell 4) was also as frequent in patients as among controls. Strong linkage between HLA-B7, DW2 and B-cell 4 occurred in controls, but not patients; the linkage was particularly striking in female controls. These data are not consistent with theories that relate certain of the histocompatibility antigens to the aetiology of multiple sclerosis.

Citing Articles

Genome-wide homozygosity and multiple sclerosis in Orkney and Shetland Islanders.

McWhirter R, Mcquillan R, Visser E, Counsell C, Wilson J Eur J Hum Genet. 2011; 20(2):198-202.

PMID: 21897447 PMC: 3260926. DOI: 10.1038/ejhg.2011.170.

Multiple sclerosis in the Orkney and Shetland Islands. V: The effect on viral titres of histocompatibility determinants.

POSKANZER D, Sever J, Terasaki P, Prenney L, Sheridan J, Park M J Epidemiol Community Health. 1980; 34(4):265-70.

PMID: 7241025 PMC: 1052089. DOI: 10.1136/jech.34.4.265.

Multiple sclerosis in the Orkney and Shetland Islands and in north-east Scotland.

Br Med J (Clin Res Ed). 1981; 282(6263):502-4.

PMID: 6780098 PMC: 1504360. DOI: 10.1136/bmj.282.6263.502-a.

HLA-linked and unlinked determinants of multiple sclerosis.

Ho H, Tiwari J, Haile R, Terasaki P, Morton N Immunogenetics. 1982; 15(5):509-17.

PMID: 6179862 DOI: 10.1007/BF00345910.

A review of the etiology of multiple sclerosis.

Vella V Ital J Neurol Sci. 1984; 5(4):347-56.

PMID: 6099345 DOI: 10.1007/BF02042616.

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