A Novel Subgenomic Murine Leukemia Virus RNA Transcript Results from Alternative Splicing

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2000 Mar 23

PMID 10729146

Citations 20

Authors

J Dejardin

M Audit

T J Hope

M Sitbon

M Mougel

Affiliations

Soon will be listed here.

Abstract

Here we show the existence of a novel subgenomic 4.4-kb RNA in cells infected with the prototypic replication-competent Friend or Moloney murine leukemia viruses (MuLV). This RNA derives by splicing from an alternative donor site (SD') within the capsid-coding region to the canonical envelope splice acceptor site. The position and the sequence of SD' was highly conserved among mammalian type C and D oncoviruses. Point mutations used to inactivate SD' without changing the capsid-coding ability affected viral RNA splicing and reduced viral replication in infected cells.

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