Modeling of Drug Release from Swellable Polymers

Overview

Journal Eur J Pharm Biopharm

Specialty Pharmacology

Date 1999 Dec 30

PMID 10613927

Citations 40

Authors

C S Brazel

N A Peppas

Affiliations

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Abstract

The water Swelling and drug diffusion from initially hydrophilic, glassy polymer matrices were modeled using concentration-dependent diffusion equations for water and drug. The transport equation for water incorporated a relaxation-dependent mechanism. These equations were solved with an appropriate boundary condition incorporating a relaxation-dependent Deborah number. Experimental results from drug release from PVA and PHEMA samples were used to determine the validity of the model.

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