Customized Hydrogel for Sustained Release of Highly Water-Soluble Drugs

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2022 Mar 21

PMID 35309415

Authors

Xin Jin

Cheng-Xiong Wei

Cheng-Wei Wu

Wei Zhang

Affiliations

Soon will be listed here.

Abstract

Highly water-soluble drugs, due to the rapid diffusion in water, are difficult to be released sustainably. To address the issue, a hydrogel with a core-shell structure is designed for the release of highly water-soluble drugs. The core is used to load the drug and the shell is devoted to isolating the drug from the release medium, which can decrease the drug concentration gradient and the driving force of drug release. The core-shell structure prolongs the drug release time by extending the drug release pathway. Moreover, the core-shell hydrogel possesses high swelling properties to reside in the stomach. The results demonstrate that the customized hydrogel can prolong the release of the highly water-soluble drug (metformin hydrochloride) for more than 50 h and alleviate the burst release of the drug.

Citing Articles

Trends in Photopolymerization 3D Printing for Advanced Drug Delivery Applications.

Hu Y, Luo Z, Bao Y Biomacromolecules. 2024; 26(1):85-117.

PMID: 39625843 PMC: 11733939. DOI: 10.1021/acs.biomac.4c01004.

Multifunctional Hydrogel with 3D Printability, Fluorescence, Biodegradability, and Biocompatibility for Biomedical Microrobots.

Wang G, Wang S, Hu T, Shi F Molecules. 2024; 29(14).

PMID: 39064931 PMC: 11279963. DOI: 10.3390/molecules29143351.

Poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) as an insulin carrier in silk fibroin hydrogels for transdermal delivery iontophoresis.

Sakunpongpitiporn P, Morarad R, Naeowong W, Niamlang S, Sirivat A RSC Adv. 2024; 14(3):1549-1562.

PMID: 38179091 PMC: 10763702. DOI: 10.1039/d3ra06857a.

A Temperature/pH Double-Responsive and Physical Double-Crosslinked Hydrogel Based on PLA and Histidine.

Wu Q, Fu Y, Yang W, Liu S Gels. 2022; 8(9).

PMID: 36135282 PMC: 9498346. DOI: 10.3390/gels8090570.

References

Razavi M, Karimian H, Yeong C, Fadaeinasab M, Khaing S, Chung L . Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy. Drug Des Devel Ther. 2016; 11:1-15. PMC: 5182038. DOI: 10.2147/DDDT.S115466. View

Kopplin G, Lervik A, Draget K, Aachmann F . Alginate gels crosslinked with chitosan oligomers - a systematic investigation into alginate block structure and chitosan oligomer interaction. RSC Adv. 2022; 11(23):13780-13798. PMC: 8697632. DOI: 10.1039/d1ra01003d. View

Khan F, Bera D, Palchaudhuri S, Bera R, Mukhopadhyay M, Dey A . Dual release kinetics in a single dosage from core-shell hydrogel scaffolds. RSC Adv. 2022; 8(57):32695-32706. PMC: 9086265. DOI: 10.1039/c8ra05358h. View

Costa P, Sousa Lobo J . Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 2001; 13(2):123-33. DOI: 10.1016/s0928-0987(01)00095-1. View

Wooster T, Acquistapace S, Mettraux C, Donato L, Dekkers B . Hierarchically structured phase separated biopolymer hydrogels create tailorable delayed burst release during gastrointestinal digestion. J Colloid Interface Sci. 2019; 553:308-319. DOI: 10.1016/j.jcis.2019.06.033. View

Brazel C, Peppas N . Modeling of drug release from swellable polymers. Eur J Pharm Biopharm. 1999; 49(1):47-58. DOI: 10.1016/s0939-6411(99)00058-2. View

Najafi-Soulari S, Shekarchizadeh H, Kadivar M . Encapsulation optimization of lemon balm antioxidants in calcium alginate hydrogels. J Biomater Sci Polym Ed. 2016; 27(16):1631-44. DOI: 10.1080/09205063.2016.1226042. View

Arun G, Rajaram R, Kaleshkumar K, Gayathri N, Sivasudha T, Kandasamy S . Synergistic effect of novel chitosan combined metformin drug on streptozotocin-induced diabetes mellitus rat. Int J Biol Macromol. 2019; 153:1335-1349. DOI: 10.1016/j.ijbiomac.2019.10.270. View

Houghton L, Read N, Heddle R, Maddern G, Downton J, Toouli J . Motor activity of the gastric antrum, pylorus, and duodenum under fasted conditions and after a liquid meal. Gastroenterology. 1988; 94(6):1276-84. DOI: 10.1016/0016-5085(88)90664-6. View

10.

Kikuchi S, Takayama K . Multivariate statistical approach to optimizing sustained-release tablet formulations containing diltiazem hydrochloride as a model highly water-soluble drug. Int J Pharm. 2009; 386(1-2):149-55. DOI: 10.1016/j.ijpharm.2009.11.008. View

11.

Bailey C . Metformin: historical overview. Diabetologia. 2017; 60(9):1566-1576. DOI: 10.1007/s00125-017-4318-z. View

12.

Wang H, Gong X, Miao Y, Guo X, Liu C, Fan Y . Preparation and characterization of multilayer films composed of chitosan, sodium alginate and carboxymethyl chitosan-ZnO nanoparticles. Food Chem. 2019; 283:397-403. DOI: 10.1016/j.foodchem.2019.01.022. View

13.

Zhang W, Jin X, Li H, Wei C, Wu C . Onion-structure bionic hydrogel capsules based on chitosan for regulating doxorubicin release. Carbohydr Polym. 2019; 209:152-160. DOI: 10.1016/j.carbpol.2019.01.028. View

14.

Bera H, Kumar S, Maiti S . Facile synthesis and characterization of tailor-made pectin-gellan gum-bionanofiller composites as intragastric drug delivery shuttles. Int J Biol Macromol. 2018; 118(Pt A):149-159. DOI: 10.1016/j.ijbiomac.2018.06.085. View

15.

Zhou Y, Jin L . Hydrolysis-induced large swelling of polyacrylamide hydrogels. Soft Matter. 2020; 16(24):5740-5749. DOI: 10.1039/d0sm00663g. View

16.

Bonnet F, Scheen A . Understanding and overcoming metformin gastrointestinal intolerance. Diabetes Obes Metab. 2016; 19(4):473-481. DOI: 10.1111/dom.12854. View