Reversal of Virus-induced Systemic Shock and Respiratory Failure by Blockade of the Lymphotoxin Pathway

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 1999 Dec 2

PMID 10581078

Citations 22

Authors

M T Puglielli

J L Browning

A W BREWER

R D Schreiber

W J Shieh

J D Altman

M B Oldstone

S R Zaki

R Ahmed

Affiliations

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Abstract

At present, little is known about the pathogenesis of acute virus-induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.

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