Fine-tuning of Dendritic Cell Biology by the TNF Superfamily

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2012 Apr 11

PMID 22487654

Citations 62

Authors

Leslie Summers deLuca

Jennifer L Gommerman

Affiliations

Soon will be listed here.

Abstract

Members of the tumour necrosis factor (TNF) superfamily have been implicated in a wide range of biological functions, and their expression by cells of the immune system makes them appealing targets for immunomodulation. One common theme for TNF superfamily members is their coordinated expression at the interface between antigen-specific T cells and antigen-presenting dendritic cells and, by virtue of this expression pattern, TNF superfamily members can shape T cell immune responses. Understanding how to manipulate such functions of the TNF superfamily may allow us to tip the balance between immunity and tolerance in the context of human disease.

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References

De Keersmaecker B, Heirman C, Corthals J, Empsen C, van Grunsven L, Allard S . The combination of 4-1BBL and CD40L strongly enhances the capacity of dendritic cells to stimulate HIV-specific T cell responses. J Leukoc Biol. 2011; 89(6):989-99. DOI: 10.1189/jlb.0810466. View

Phan T, Green J, Gray E, Xu Y, Cyster J . Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation. Nat Immunol. 2009; 10(7):786-93. PMC: 2776777. DOI: 10.1038/ni.1745. View

Tone M, Tone Y, Adams E, Yates S, Frewin M, Cobbold S . Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc Natl Acad Sci U S A. 2003; 100(25):15059-64. PMC: 299905. DOI: 10.1073/pnas.2334901100. View

Peters A, Stunz L, Bishop G . CD40 and autoimmunity: the dark side of a great activator. Semin Immunol. 2009; 21(5):293-300. PMC: 2753170. DOI: 10.1016/j.smim.2009.05.012. View

Suresh M, Lanier G, Large M, Whitmire J, Altman J, Ruddle N . Role of lymphotoxin alpha in T-cell responses during an acute viral infection. J Virol. 2002; 76(8):3943-51. PMC: 136110. DOI: 10.1128/jvi.76.8.3943-3951.2002. View

Keller A, Schildknecht A, Xiao Y, van den Broek M, Borst J . Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunity. Immunity. 2008; 29(6):934-46. DOI: 10.1016/j.immuni.2008.10.009. View

Moussion C, Girard J . Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules. Nature. 2011; 479(7374):542-6. DOI: 10.1038/nature10540. View

Kumar V, Scandella E, Danuser R, Onder L, Nitschke M, Fukui Y . Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotoxin-dependent pathway. Blood. 2010; 115(23):4725-33. DOI: 10.1182/blood-2009-10-250118. View

Guo Z, Wang J, Meng L, Wu Q, Kim O, Hart J . Cutting edge: membrane lymphotoxin regulates CD8(+) T cell-mediated intestinal allograft rejection. J Immunol. 2001; 167(9):4796-800. DOI: 10.4049/jimmunol.167.9.4796. View

10.

Kong Y, Yoshida H, Sarosi I, Tan H, Timms E, Capparelli C . OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999; 397(6717):315-23. DOI: 10.1038/16852. View

11.

Josien R, Li H, Ingulli E, Sarma S, Wong B, Vologodskaia M . TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivo. J Exp Med. 2000; 191(3):495-502. PMC: 2195824. DOI: 10.1084/jem.191.3.495. View

12.

Lewis K, Caton M, Bogunovic M, Greter M, Grajkowska L, Ng D . Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity. 2011; 35(5):780-91. PMC: 3225703. DOI: 10.1016/j.immuni.2011.08.013. View

13.

Snell L, McPherson A, Lin G, Sakaguchi S, Pandolfi P, Riccardi C . CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection. J Immunol. 2010; 185(12):7223-34. DOI: 10.4049/jimmunol.1001912. View

14.

Chyou S, Benahmed F, Chen J, Kumar V, Tian S, Lipp M . Coordinated regulation of lymph node vascular-stromal growth first by CD11c+ cells and then by T and B cells. J Immunol. 2011; 187(11):5558-67. PMC: 3221869. DOI: 10.4049/jimmunol.1101724. View

15.

Feldmann M, Maini R . Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med. 2003; 9(10):1245-50. DOI: 10.1038/nm939. View

16.

McLachlan J, Hart J, Pizzo S, Shelburne C, Staats H, Gunn M . Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. Nat Immunol. 2003; 4(12):1199-205. DOI: 10.1038/ni1005. View

17.

Stephens G, McHugh R, Whitters M, Young D, Luxenberg D, Carreno B . Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J Immunol. 2004; 173(8):5008-20. DOI: 10.4049/jimmunol.173.8.5008. View

18.

Bekiaris V, Gaspal F, Kim M, Withers D, McConnell F, Anderson G . CD30 is required for CCL21 expression and CD4 T cell recruitment in the absence of lymphotoxin signals. J Immunol. 2009; 182(8):4771-5. DOI: 10.4049/jimmunol.0803481. View

19.

DE TOGNI P, Goellner J, Ruddle N, Streeter P, Fick A, Mariathasan S . Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994; 264(5159):703-7. DOI: 10.1126/science.8171322. View

20.

Leibbrandt A, Penninger J . Novel functions of RANK(L) signaling in the immune system. Adv Exp Med Biol. 2009; 658:77-94. DOI: 10.1007/978-1-4419-1050-9_9. View