Aging and Reproductive Potential in Women

Overview

Journal Yale J Biol Med

Specialty Biology

Date 1999 Oct 20

PMID 10527364

Citations 17

Authors

C Fitzgerald

A E Zimon

E E Jones

Affiliations

Soon will be listed here.

Abstract

Reproductive potential in women declines with age. Age-related changes in the ovary account for most of this loss of reproductive function. Oocytes, all of which are present at birth, decline in number and quality with age. The endocrine function of the ovary also declines with age, and the ovary becomes unable to sustain its normal function in the neuroendocrine axis. The neuroendocrine axis may be further affected by primary changes occurring in the hypothalamus and pituitary during aging, although this has not been established in humans. Aging also affects the function of the uterus as the endometrium loses its ability to support implantation and growth of an embryo. Diminished uterine function during aging may be due to changes in the uterine vasculature or to changes in the hormone-dependent development of the endometrium. Finally, aging increases a woman's risk of developing medical, gynecologic or obstetric conditions that may impair her fertility. Knowledge of these affects of aging on a woman's reproductive function is essential to advise and treat the growing number of women seeking pregnancy at advanced reproductive age.

Citing Articles

Oocyte Health and Quality: Implication of Mitochondria-related Organelle Interactions.

Udagawa O Results Probl Cell Differ. 2024; 73:25-42.

PMID: 39242373 DOI: 10.1007/978-3-031-62036-2_2.

Stem cell-based therapeutic potential in female ovarian aging and infertility.

Cui X, Jing X J Ovarian Res. 2024; 17(1):171.

PMID: 39182123 PMC: 11344413. DOI: 10.1186/s13048-024-01492-3.

Differential age-related transcriptomic analysis of ovarian granulosa cells in Kazakh horses.

Ren W, Wang J, Zeng Y, Wang T, Meng J, Yao X Front Endocrinol (Lausanne). 2024; 15:1346260.

PMID: 38352714 PMC: 10863452. DOI: 10.3389/fendo.2024.1346260.

Coenzyme Q10 levels increase with embryonic development in medaka.

Okamoto M, Nakamura A, Maeda A, Kameda Y, Sugawara K, Takekawa M J Clin Biochem Nutr. 2022; 70(3):231-239.

PMID: 35692673 PMC: 9130062. DOI: 10.3164/jcbn.21-148.

Uterine-specific SIRT1 deficiency confers premature uterine aging and impairs invasion and spacing of blastocyst, and stromal cell decidualization, in mice.

Cummings M, Yu H, Paudel S, Hu G, Li X, Hemberger M Mol Hum Reprod. 2022; 28(7).

PMID: 35536234 PMC: 10689003. DOI: 10.1093/molehr/gaac016.

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