Preliminary Evidence of Low Cortical GABA Levels in Localized 1H-MR Spectra of Alcohol-dependent and Hepatic Encephalopathy Patients

Overview

Journal Am J Psychiatry

Specialty Psychiatry

Date 1999 Jun 9

PMID 10360140

Citations 56

Authors

K L Behar

D L Rothman

K F Petersen

M Hooten

R Delaney

O A Petroff

G I Shulman

V Navarro

I L Petrakis

D S Charney

J H Krystal

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of the study was to compare levels of neuroactive amino acids in the cerebral cortex of healthy subjects, recently detoxified alcohol-dependent patients, and patients with hepatic encephalopathy.

Method: Metabolite levels were measured in the occipital cortex by using spatially localized 1H-MRS. Five recently detoxified alcohol-dependent and five hepatic encephalopathy patients with alcohol and non-alcohol-related disease were compared with 10 healthy subjects.

Results: The combined level of gamma-aminobutyric acid (GABA) plus homocarnosine was lower in the alcohol-dependent and hepatic encephalopathy patients than in the healthy subjects.

Conclusions: The findings suggest that GABA-ergic systems are altered in both alcohol-dependent and hepatic encephalopathy patients.

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