Human Herpesvirus 6 Latently Infects Mononuclear Cells but Not Liver Tissue

Overview

Journal J Clin Pathol

Specialty Pathology

Date 1999 May 27

PMID 10343615

Citations 1

Authors

T Yoshikawa

K Suzuki

M Ihira

H Furukawa

S Suga

T Iwasaki

T Kurata

K Asonuma

K Tanaka

Y Asano

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate whether human herpesvirus 6 (HHV-6) can cause latent infection of liver tissue.

Methods: Peripheral blood and liver tissue were collected from 25 living related liver transplant recipients at the time of transplantation. An avidin-biotin complex peroxidase method was used to identify HHV-6 antigen in the liver tissue. A nested polymerase chain reaction (PCR) was used to detect HHV-6 DNA in the liver tissue and mononuclear cells. Variant of HHV-6 was determined by the presence of the Hind III site in a second PCR product.

Results: Immunohistochemical analysis for HHV-6 antigen was negative in all the liver specimens. HHV-6 DNA was not detected in liver tissue. Virus DNA was detected in peripheral blood mononuclear cells in nine of 25 recipients. All nine HHV-6 identified in the mononuclear cells were variant B.

Conclusions: HHV-6 variant B latently infects mononuclear cells but not liver tissue.

Citing Articles

Frequent detection of the human herpesvirus 6-specific genomes in the livers of children with various liver diseases.

Ozaki Y, Tajiri H, Tanaka-Taya K, Mushiake S, Kimoto A, Yamanishi K J Clin Microbiol. 2001; 39(6):2173-7.

PMID: 11376053 PMC: 88107. DOI: 10.1128/JCM.39.6.2173-2177.2001.

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