Brief Report: Primary Human Herpesvirus 6 Infection in a Patient Following Liver Transplantation from a Seropositive Donor

Overview

Journal J Med Virol

Specialty Microbiology

Date 1989 Jun 1

PMID 2544678

Citations 21

Authors

K N Ward

J J Gray

S Efstathiou

Affiliations

Soon will be listed here.

Abstract

A virus, isolated from peripheral blood lymphocytes of a patient 23 days after liver transplantation, was identified by negative contrast and thin-section electron microscopy, DNA hybridisation, and immunofluorescence as human herpesvirus 6 (HHV-6). The patient was seronegative for antibodies to HHV-6 before receiving the liver from a seropositive donor. Seroconversion for IgM and IgG antibodies occurred at the same time as the viraemia, indicating a primary response to HHV-6 infection that was probably acquired from the donor liver. The relationship of the infection to the patient's subsequent disease episodes is discussed.

Citing Articles

Asymptomatic viruses detectable in saliva in the first year of life: a narrative review.

Goh M, Joy C, Gillespie A, Soh Q, He F, Sung V Pediatr Res. 2023; 95(2):508-531.

PMID: 38135726 DOI: 10.1038/s41390-023-02952-0.

The Interplay between Natural Killer Cells and Human Herpesvirus-6.

Eliassen E, Di Luca D, Rizzo R, Barao I Viruses. 2017; 9(12).

PMID: 29194419 PMC: 5744142. DOI: 10.3390/v9120367.

Laboratory and clinical aspects of human herpesvirus 6 infections.

Agut H, Bonnafous P, Gautheret-Dejean A Clin Microbiol Rev. 2015; 28(2):313-35.

PMID: 25762531 PMC: 4402955. DOI: 10.1128/CMR.00122-14.

Acute arthropathy in patients with rash diseases: a comparative study.

de Oliveira S, Camacho L, Fernandes Bruno L, Gusmao R, de Medeiros Pereira A, Velarde L Clin Rheumatol. 2009; 28(9):1067-71.

PMID: 19415376 DOI: 10.1007/s10067-009-1184-1.

Human herpesvirus 6 DNA levels in cerebrospinal fluid due to primary infection differ from those due to chromosomal viral integration and have implications for diagnosis of encephalitis.

Ward K, Leong H, Thiruchelvam A, Atkinson C, Clark D J Clin Microbiol. 2007; 45(4):1298-304.

PMID: 17229866 PMC: 1865851. DOI: 10.1128/JCM.02115-06.