The FEZ1 Gene at Chromosome 8p22 Encodes a Leucine-zipper Protein, and Its Expression is Altered in Multiple Human Tumors

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1999 Mar 31

PMID 10097140

Citations 43

Authors

H Ishii

R Baffa

S I Numata

Y Murakumo

S Rattan

H Inoue

M Mori

V Fidanza

H Alder

C M Croce

Affiliations

Soon will be listed here.

Abstract

Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis. cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. RNA blot analysis revealed that FEZ1 gene expression was undetectable in more than 60% of epithelial tumors. Mutations were found in primary esophageal cancers and in a prostate cancer cell line. Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors.

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