Inhibition of Human Esophageal Squamous Cell Carcinomas by Targeted Silencing of Tumor Enhancer Genes: an Overview

Overview

Journal Cancer Biol Med

Specialty Oncology

Date 2014 Jul 11

PMID 25009749

Citations 6

Authors

Jalil Pirayesh Islamian

Mohsen Mohammadi

Behzad Baradaran

Affiliations

Soon will be listed here.

Abstract

Esophageal cancer has been reported as the ninth most common malignancy and ranks as the sixth most frequent cause of death worldwide. Esophageal cancer treatment involves surgery, chemotherapy, radiation therapy, or combination therapy. Novel strategies are needed to boost the oncologic outcome. Recent advances in the molecular biology of esophageal cancer have documented the role of genetic alterations in tumorigenesis. Oncogenes serve a pivotal function in tumorigenesis. Targeted therapies are directed at the unique molecular signature of cancer cells for enhanced efficacy with low toxicity. RNA interference (RNAi) technology is a powerful tool for silencing endogenous or exogenous genes in mammalian cells. Related results have shown that targeting oncogenes with siRNAs, specifically the mRNA, effectively reduces tumor cell proliferation and induces apoptotic cell death. This article will briefly review studies on silencing tumor enhancer genes related to the induction of esophageal cancer.

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