Protein Phosphatase 1 Regulatory Subunit 3: A Prognostic Biomarker in Stomach Adenocarcinoma

Overview

Journal Int J Gen Med

Publisher Dove Medical Press

Specialty General Medicine

Date 2022 Feb 14

PMID 35153505

Authors

Ya-Zhen Zhu

Xi-Wen Liao

Wu Yin

Hai-Ming Wei

Affiliations

Soon will be listed here.

Abstract

Purpose: This study aimed to determine the potential application of the protein phosphatase 1 regulatory subunit 3 () gene as a prognostic marker in stomach adenocarcinoma (STAD), as well as its potential mediating biological processes and pathways.

Materials And Methods: Differential expression analyses were performed using the TIMER2.0 and UALCAN databases. Complete RNA-seq data and other relevant clinical and survival data were acquired from The Cancer Genome Atlas (TCGA). Univariate survival analyses, Cox regression modelling, and Kaplan-Meier curves were implemented to investigate the associations between gene expression and clinical pathologic features. A genome wide gene set enrichment analysis (GSEA) was conducted to define the underlying molecular mechanisms mediating the observed associations between the gene and STAD development.

Results: We found that was overexpressed in STAD tissues, and that higher expression correlated with worse prognoses in patients with STAD. Comprehensive survival analyses suggested that might be an independent predictive factor for survival time in patients with STAD. The prognostic relationship between and STAD was also verified using Kaplan-Meier curves. Patients with higher levels had a shorter clinical survival time on average. Additionally, a GSEA demonstrated that might be involved in multiple biological processes and pathways.

Conclusion: Our findings demonstrate that the gene has utility as a potential molecular marker for STAD prognoses.

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