Carnosine: an Endogenous Neuroprotector in the Ischemic Brain

Overview

Journal Cell Mol Neurobiol

Publisher Springer

Specialties Cell Biology
Molecular Biology
Neurology

Date 1999 Mar 18

PMID 10079964

Citations 7

Authors

S L Stvolinsky

M L Kukley

D Dobrota

M Matejovicova

I Tkac

A A Boldyrev

Affiliations

Soon will be listed here.

Abstract

1. The biological effects of carnosine, a natural hydrophilic neuropeptide, on the reactive oxygen species (ROS) pathological generation are reviewed. 2. We describe direct antioxidant action observed in the in vitro experiments. 3. Carnosine was found to effect metabolism indirectly. These effects are reflected in ROS turnover regulation and lipid peroxidation (LPO) processes. 4. During brain ischemia carnosine acts as a neuroprotector, contributing to better cerebral blood flow restoration, electroencephalography (EEG) normalization, decreased lactate accumulation, and enzymatic protection against ROS. 5. The data presented demonstrate that carnosine is a specific regulator of essential metabolic pathways in neurons supporting brain homeostasis under unfavorable conditions.

Citing Articles

Effects of Carnosine (Beta-Alanyl-L-Histidine) in an Experimental Rat Model of Acute Kidney Injury Due to Septic Shock.

Sahin S, Donmez D Med Sci Monit. 2018; 24:305-316.

PMID: 29334583 PMC: 5778771. DOI: 10.12659/msm.905181.

The effects of carnosine in an experimental rat model of septic shock.

Sahin S, Oter S, Burukoglu D, Sutken E Med Sci Monit Basic Res. 2013; 19:54-61.

PMID: 23396325 PMC: 3940703. DOI: 10.12659/msmbr.883758.

Neuroprotective role of lipoic acid against acute toxicity of N-acetylaspartic acid.

Pederzolli C, Rosa A, de Oliveira A, Coelho J, da Luz Becker D, Dalazen G Mol Cell Biochem. 2010; 344(1-2):231-9.

PMID: 20686917 DOI: 10.1007/s11010-010-0547-x.

Effects of carnosine on long-term plasticity of medial perforant pathway/dentate gyrus synapses in urethane-anesthetized rats: an in vivo model.

Suer C, Dolu N, Artis S, Aydogan S Exp Brain Res. 2009; 197(2):135-42.

PMID: 19554317 DOI: 10.1007/s00221-009-1899-x.

Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice.

Kamal M, Jiang H, Hu Y, Keep R, Smith D Am J Physiol Regul Integr Comp Physiol. 2009; 296(4):R986-91.

PMID: 19225147 PMC: 2698603. DOI: 10.1152/ajpregu.90744.2008.

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