Metabolic Transformation of Neuropeptide Carnosine Modifies Its Biological Activity

Overview

Journal Cell Mol Neurobiol

Publisher Springer

Specialties Cell Biology
Molecular Biology
Neurology

Date 1999 Mar 18

PMID 10079975

Citations 8

Authors

A Boldyrev

H Abe

Affiliations

Soon will be listed here.

Abstract

1. The ability of carnosine and carnosine-related compounds (CRCs) to interact with several free oxygen radicals is analyzed. 2. Carnosine, the CRCs (imidazole, histidine, anserine), and ergothioneine were found to be equally efficient in singlet oxygen quenching. During generation of hydroxyl radicals from hydrogen peroxide in the Fenton reaction, carnosine was found to be more effective than the CRCs tested. 3. By measuring the chemiluminescence produced by carnosine and CRCs in rabbit leukocytes in the presence of luminol or lucigenin, we conclude that carnosine and other CRCs play a stimulating role in superoxide oxygen production while suppressing the myeloperoxidase system. 4. ADP-induced aggregation of human platelets is slightly stimulated by carnosine but is inhibited by acetylanserine. 5. The following rank order of efficiency of CRCs was demonstrated while measuring the oxidation of human serum lipoproteins: acetylcarnosine < acetylanserine < homocarnosine = ophidine < carnosine < anserine. 6. The results obtained demonstrate that metabolic transformation of carnosine into CRCs in tissues may play an important role in regulating the native antioxidant status of the organism.

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References

Bauer K, Hallermayer K, Salnikow J, Kleinkauf H, Hamprecht B . Biosynthesis of carnosine and related peptides by glial cells in primary culture. J Biol Chem. 1982; 257(7):3593-7. View

Smith E . The buffering of muscle in rigor; protein, phosphate and carnosine. J Physiol. 1938; 92(3):336-43. PMC: 1395289. DOI: 10.1113/jphysiol.1938.sp003605. View

Boldyrev A, Petukhov V . Localization of carnosine effect on the fatigued muscle preparation. Gen Pharmacol. 1978; 9(1):17-20. DOI: 10.1016/0306-3623(78)90051-4. View

Evstigneeva R, Zheltukhina G, Ageeva E, Babizhaev M . [Lipoperoxidase activity of carnosine and carcinine]. Dokl Akad Nauk. 1993; 333(1):104-6. View

Brown C, Antholine W . Evidence that carnosine and anserine may participate in Wilson's disease. Biochem Biophys Res Commun. 1980; 92(2):470-7. DOI: 10.1016/0006-291x(80)90357-5. View

Raghavan M, Lindberg U, Schutt C . The use of alternative substrates in the characterization of actin-methylating and carnosine-methylating enzymes. Eur J Biochem. 1992; 210(1):311-8. DOI: 10.1111/j.1432-1033.1992.tb17423.x. View

Rebrova O, Boldyrev A . [Carnosine and related compounds inhibit chemiluminescence of human plasma lipoproteins in vitro]. Biull Eksp Biol Med. 1995; 119(2):152-4. View

Dahl T, Midden W, Hartman P . Some prevalent biomolecules as defenses against singlet oxygen damage. Photochem Photobiol. 1988; 47(3):357-62. DOI: 10.1111/j.1751-1097.1988.tb02737.x. View

ODowd A, ODowd J, MacFarlane N, Abe H, Miller D . Analysis of novel imidazoles from isolated perfused rabbit heart by two high-performance liquid chromatographic methods. J Chromatogr. 1992; 577(2):347-53. DOI: 10.1016/0378-4347(92)80257-q. View

10.

Davey C . The significance of carnosine and anserine in striated skeletal muscle. Arch Biochem Biophys. 1960; 89:303-8. DOI: 10.1016/0003-9861(60)90059-x. View

11.

Hartman P, Hartman Z, Ault K . Scavenging of singlet molecular oxygen by imidazole compounds: high and sustained activities of carboxy terminal histidine dipeptides and exceptional activity of imidazole-4-acetic acid. Photochem Photobiol. 1990; 51(1):59-66. DOI: 10.1111/j.1751-1097.1990.tb01684.x. View

12.

Pavlov A, Revina A, Dupin A, Boldyrev A, Yaropolov A . The mechanism of interaction of carnosine with superoxide radicals in water solutions. Biochim Biophys Acta. 1993; 1157(3):304-12. DOI: 10.1016/0304-4165(93)90114-n. View

13.

Nagai K, Suda T, Kawasaki K, Mathuura S . Action of carnosine and beta-alanine on wound healing. Surgery. 1986; 100(5):815-21. View

14.

Czapski G . Reaction of .OH. Methods Enzymol. 1984; 105:209-15. DOI: 10.1016/s0076-6879(84)05027-8. View

15.

Guliaeva N . [Superoxide-scavenging activity of carnosine in the presence of copper and zinc ions]. Biokhimiia. 1987; 52(7):1216-20. View

16.

Aruoma O, Laughton M, Halliwell B . Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo?. Biochem J. 1989; 264(3):863-9. PMC: 1133665. DOI: 10.1042/bj2640863. View

17.

FITZPATRICK J, Fisher H, Flancbaum L . Mobilization of renal carnosine and histidine to histamine during compound-48/80-induced shock. Nephron. 1991; 59(2):299-303. DOI: 10.1159/000186568. View

18.

Chasovnikova L, Formazyuk V, Sergienko V, Boldyrev A, Severin S . The antioxidative properties of carnosine and other drugs. Biochem Int. 1990; 20(6):1097-103. View

19.

Stvolinsky S, Kukley M, Dobrota D, Matejovicova M, Tkac I, Boldyrev A . Carnosine: an endogenous neuroprotector in the ischemic brain. Cell Mol Neurobiol. 1999; 19(1):45-56. PMC: 11545408. DOI: 10.1023/a:1006960407008. View

20.

Quinn P, Boldyrev A, Formazuyk V . Carnosine: its properties, functions and potential therapeutic applications. Mol Aspects Med. 1992; 13(5):379-444. DOI: 10.1016/0098-2997(92)90006-l. View