Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Overview
Xenobiotica is a renowned scientific journal that focuses on the study of foreign compounds in biological systems. It provides a platform for researchers to explore the fate, metabolism, and toxicology of xenobiotics, including drugs, environmental pollutants, and other foreign substances. With its multidisciplinary approach, Xenobiotica offers valuable insights into the interactions between these compounds and living organisms, contributing to advancements in pharmacology, toxicology, and environmental sciences.
Details
Details
Abbr.
Xenobiotica
Publisher
Informa Healthcare
Start
1971
End
Continuing
Frequency
Monthly
p-ISSN
0049-8254
e-ISSN
1366-5928
Country
United Kingdom
Language
English
Specialties
Biochemistry
Toxicology
Toxicology
Metrics
Metrics
h-index / Ranks: 3747
89
SJR / Ranks: 10567
387
CiteScore / Ranks: 7049
3.80
JIF / Ranks: 5564
1.8
Recent Articles
11.
Dankovic K, Stefanovic N, Cvetkovic T, Vujic S, Jovic M, Mitic B, et al.
Xenobiotica
. 2024 Nov;
54(10):855-863.
PMID: 39535282
1. Introduction: The study aimed to investigate the influence of interleukin (IL)-6 -174 G/C gene polymorphism on graft function (defined as estimated glomerular filtration rate, eGFR), as well as on...
12.
Medeiros da Silva F, Pena Modesto R, Cavoli Lira M, Libanio Reis Santos E, Oliveira-Lima J
Xenobiotica
. 2024 Nov;
54(10):840-846.
PMID: 39535153
Benzophenone-3 (BP-3), commonly known as oxybenzone, is an organic compound that acts as a sunscreen, protecting the skin from UVA and UVB rays. Thus, the objective of this study was...
13.
Wang L, Zhao J, Zhou F, Lan J, Lu Q, Ren H
Xenobiotica
. 2024 Nov;
54(10):831-839.
PMID: 39526731
GFH009 is a potent and highly selective cyclin-dependent kinase 9 (CDK9) inhibitor currently under phase II clinical trials. In this study, we investigated the metabolism and disposition of GFH009 in...
14.
Li X
Xenobiotica
. 2024 Oct;
54(10):847-854.
PMID: 39445918
The drug-drug interaction (DDI) and CYP2C19 genetic variation can lead to a high blood concentration of voriconazole. CYP2C19 is a highly genetically polymorphic enzyme, and CYP2C19*2 is more frequent among...
15.
Salphati L, Pang J, Plise E, Cheong J, Braun M, Friedman L, et al.
Xenobiotica
. 2024 Oct;
54(10):808-820.
PMID: 39387185
1. Small molecule inhibitors of the PI3K pathway have been extensively investigated as potential anticancer agents. Among the effectors in this pathway, PI3Kα is the kinase most frequently associated with...
16.
Bhattiprolu A, Kollipara S, Boddu R, Ahmed T
Xenobiotica
. 2024 Oct;
54(10):781-795.
PMID: 39361244
Drug products meeting the dissolution specifications is crucial in order to ensure consistent clinical performance. However, in certain cases, wider dissolution specifications may be required based on product behaviour. While...
17.
Araujo F, Doria M, Beliaev A, Kiss L, Bonifacio M, Holenz J, et al.
Xenobiotica
. 2024 Oct;
54(10):796-807.
PMID: 39359020
The metabolism and disposition of zamicastat, a reversible dopamine β-hydroxylase (DβH) inhibitor, developed for treatment of Pulmonary Arterial Hypertension (PAH), were investigated in rats after oral and intravenous administration of...
18.
Moore E, Rice M, Roy G, Zhang W, Marelli M
Xenobiotica
. 2024 Sep;
54(8):469-491.
PMID: 39329289
Antibody drug conjugates are an exciting therapeutic modality that combines the targeting specificity of antibodies with potent cytotoxins to selectively kill cancer cells. The targeting component improves efficacy and protects...
19.
Hengel S, Topletz-Erickson A, Kadry H, Alley S
Xenobiotica
. 2024 Sep;
54(8):492-501.
PMID: 39329288
Native liquid chromatography mass spectrometry (LC-MS) is a commonly used approach for intact analysis of inter-chain cysteine conjugated antibody-drug conjugates (ADCs). Coupling native LC-MS with affinity capture provides a platform...
20.
Rudolph B, Davis J, Hainzl D, Walles M
Xenobiotica
. 2024 Sep;
54(8):521-532.
PMID: 39329287
Antibody-drug conjugates (ADCs) are a class of biopharmaceuticals that combine the specificity of monoclonal antibodies (mAbs) with the cytotoxicity of small molecule drugs. 15 ADCs have been approved by regulatory...