Zulfeqhar A Syed
Overview
Explore the profile of Zulfeqhar A Syed including associated specialties, affiliations and a list of published articles.
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12
Citations
234
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Recent Articles
1.
Prabahran A, Wu L, Manley A, Wu Z, Gao S, Mizumaki H, et al.
Blood Adv
. 2025 Mar;
PMID: 40086077
Megakaryocytes (MKs) serve diverse roles beyond platelet production, including hematopoietic stem cell maintenance and immune response modulation. In our mouse model of immune bone marrow failure (BMF), we observed the...
2.
Elezaby A, Lin A, Vijayan V, Pokhrel S, Kraemer B, Bechara L, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(8):987-1002.
PMID: 39196031
Cardiac troponin I (cTnI) is a key regulator of cardiomyocyte contraction. However, its role in mitochondria is unknown. Here we show that cTnI localized to mitochondria in the heart, inhibited...
3.
Zhang L, Muirhead K, Syed Z, Dimitriadis E, Ten Hagen K
Proc Natl Acad Sci U S A
. 2024 Jan;
121(6):e2314309121.
PMID: 38285943
Mucins are large, highly glycosylated extracellular matrix proteins that line and protect epithelia of the respiratory, digestive, and urogenital tracts. Previous work has shown that mucins form large, interconnected polymeric...
4.
Nyenhuis S, Wu X, Strub M, Yim Y, Stanton A, Baena V, et al.
Nature
. 2023 Aug;
620(7976):1109-1116.
PMID: 37612506
Dominant optic atrophy is one of the leading causes of childhood blindness. Around 60-80% of cases are caused by mutations of the gene that encodes optic atrophy protein 1 (OPA1),...
5.
Tian E, Syed Z, Edin M, Zeldin D, Ten Hagen K
Glycobiology
. 2023 Apr;
33(6):476-489.
PMID: 37115803
The COVID-19 global pandemic has underscored the need to understand how viruses and other pathogens are able to infect and replicate within the respiratory system. Recent studies have highlighted the...
6.
Lee B, Zhou Y, Bresciani E, Ozkaya N, Dulau-Florea A, Carrington B, et al.
Blood
. 2022 Nov;
141(3):231-237.
PMID: 36322931
Germ line loss-of-function heterozygous mutations in the RUNX1 gene cause familial platelet disorder with associated myeloid malignancies (FPDMM) characterized by thrombocytopenia and a life-long risk of hematological malignancies. Although gene...
7.
Syed Z, Zhang L, Tran D, Bleck C, Ten Hagen K
Proc Natl Acad Sci U S A
. 2022 Oct;
119(43):e2209750119.
PMID: 36252017
Mucins are large, highly glycosylated transmembrane and secreted proteins that line and protect epithelial surfaces. However, the details of mucin biosynthesis and packaging in vivo are largely unknown. Here, we...
8.
Syed Z, Zhang L, Ten Hagen K
Adv Drug Deliv Rev
. 2022 Mar;
184:114182.
PMID: 35278522
The secreted mucus layer that lines and protects epithelial cells is conserved across diverse species. While the exact composition of this protective layer varies between organisms, certain elements are conserved,...
9.
Zhang L, Mann M, Syed Z, Reynolds H, Tian E, Samara N, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(47).
PMID: 34732583
The SARS-CoV-2 coronavirus responsible for the global pandemic contains a novel furin cleavage site in the spike protein (S) that increases viral infectivity and syncytia formation in cells. Here, we...
10.
May C, Ji S, Syed Z, Revoredo L, Daniel E, Gerken T, et al.
J Biol Chem
. 2020 Jul;
295(35):12525-12536.
PMID: 32669364
Mucin-type -glycosylation is an essential post-translational modification required for protein secretion, extracellular matrix formation, and organ growth. -Glycosylation is initiated by a large family of enzymes (GALNTs in mammals and...