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Zubaida Saifudeen

Explore the profile of Zubaida Saifudeen including associated specialties, affiliations and a list of published articles. Areas
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Articles 40
Citations 708
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Recent Articles
1.
Yanofsky S, Dugas C, Katsurada A, Liu J, Saifudeen Z, El-Dahr S, et al.
Am J Physiol Renal Physiol . 2021 Aug; 321(5):F559-F571. PMID: 34448643
Human kidney organoid technology holds promise for novel kidney disease treatment strategies and utility in pharmacological and basic science. Given the crucial roles of the intrarenal renin-angiotensin system (RAS) and...
2.
Wang F, Ngo J, Li Y, Liu H, Chen C, Saifudeen Z, et al.
Epigenetics . 2020 Dec; 16(11):1235-1250. PMID: 33315499
The epigenetic regulator Dot1, the only known histone H3K79 methyltransferase, has a conserved role in organismal development and homoeostasis. In yeast, is required for telomeric silencing and genomic integrity. In...
3.
Tortelote G, Colon-Leyva M, Saifudeen Z
Pediatr Nephrol . 2020 Oct; 36(8):2155-2164. PMID: 33089379
Metabolic pathways are one of the first responses at the cellular level to maternal/fetal interface stressors. Studies have revealed the previously unrecognized contributions of intermediary metabolism to developmental programs. Here,...
4.
Liu H, Hilliard S, Kelly E, Chen C, Saifudeen Z, El-Dahr S
J Biol Chem . 2020 Jun; 295(33):11542-11558. PMID: 32554463
SIX2 (SIX homeobox 2)-positive nephron progenitor cells (NPCs) give rise to all epithelial cell types of the nephron, the filtering unit of the kidney. NPCs have a limited lifespan and...
5.
Cargill K, Hemker S, Clugston A, Murali A, Mukherjee E, Liu J, et al.
J Am Soc Nephrol . 2019 May; 30(7):1192-1205. PMID: 31142573
Background: Nephron progenitors, the cell population that give rise to the functional unit of the kidney, are metabolically active and self-renew under glycolytic conditions. A switch from glycolysis to mitochondrial...
6.
Hilliard S, Song R, Liu H, Chen C, Li Y, Baddoo M, et al.
Biol Open . 2019 May; 8(5). PMID: 31064740
Six2 cap mesenchyme cells, also called nephron progenitor cells (NPC), are precursors of all epithelial cell types of the nephron, the filtering unit of the kidney. Current evidence indicates that...
7.
El-Dahr S, Saifudeen Z
Semin Cell Dev Biol . 2018 Sep; 91:111-118. PMID: 30172047
Developmental changes in cell fate are tightly regulated by cell-type specific transcription factors. Chromatin reorganization during organismal development ensures dynamic access of developmental regulators to their cognate DNA sequences. Thus,...
8.
Zwezdaryk K, Sullivan D, Saifudeen Z
Front Endocrinol (Lausanne) . 2018 Aug; 9:457. PMID: 30158901
Obesity and the resultant metabolic complications have been associated with an increased risk of cancer. In addition to the systemic metabolic disturbances in obesity that are associated with cancer initiation...
9.
Liu H, Chen S, Yao X, Li Y, Chen C, Liu J, et al.
Development . 2018 May; 145(10). PMID: 29712641
Nephron progenitor cells (NPCs) are Six2-positive metanephric mesenchyme cells, which undergo self-renewal and differentiation to give rise to nephrons until the end of nephrogenesis. Histone deacetylases (HDACs) are a group...
10.
Altassan R, Witters P, Saifudeen Z, Quelhas D, Jaeken J, Levtchenko E, et al.
Mol Genet Metab . 2017 Dec; 123(3):292-296. PMID: 29229467
Phosphomannomutase 2 deficiency (PMM2-CDG) is the most common N-linked glycosylation disorder. The majority of patients present with a multisystem phenotype, including central nervous system involvement, hepatopathy, gastrointestinal and cardiac symptoms,...