Zikun Chen
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Explore the profile of Zikun Chen including associated specialties, affiliations and a list of published articles.
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12
Citations
130
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Recent Articles
1.
Zheng G, Wu D, Wei X, Xu D, Mao T, Yan D, et al.
Brief Bioinform
. 2025 Jan;
26(1.
PMID: 39798999
Nuclear receptors (NRs) are a class of essential proteins that regulate the expression of specific genes and are associated with multiple diseases. In silico methods for prescreening potential NR binders...
2.
Gao J, Mo S, Wang J, Zhang M, Shi Y, Zhu C, et al.
Nucleic Acids Res
. 2023 Oct;
52(D1):D633-D639.
PMID: 37897362
Metabolite-associated cell communications play critical roles in maintaining the normal biological function of human through coordinating cells, organs and physiological systems. Though substantial information of MACCs has been continuously reported,...
3.
Qiu T, Zhang L, Chen Z, Wang Y, Mao T, Wang C, et al.
Nucleic Acids Res
. 2023 May;
51(W1):W528-W534.
PMID: 37216611
Identifying the exact epitope positions for a monoclonal antibody (mAb) is of critical importance yet highly challenging to the Ab design of biomedical research. Based on previous versions of SEPPA...
4.
Blatti C, de la Fuente J, Gao H, Marin-Goni I, Chen Z, Zhao S, et al.
Cancer Res
. 2023 Feb;
83(8):1361-1380.
PMID: 36779846
Significance: The computational method TraRe built on Bayesian machine learning models for investigating transcriptional network structures shows that disruption of ELK3, MXD1, and MYB signaling cascades impacts abiraterone resistance in...
5.
Chen Z, Yan D, Zhang M, Han W, Wang Y, Xu S, et al.
Front Chem
. 2022 Jun;
10:881975.
PMID: 35646826
Natural compounds (NCs) undergo complicated biotransformation to produce diverse forms of metabolites dynamically, many of which are of high medicinal value. Predicting the profiles of chemical products may help to...
6.
Yan D, Zheng G, Wang C, Chen Z, Mao T, Gao J, et al.
Nucleic Acids Res
. 2022 Jan;
50(D1):D1238-D1243.
PMID: 34986599
Literature-described targets of herbal ingredients have been explored to facilitate the mechanistic study of herbs, as well as the new drug discovery. Though several databases provided similar information, the majority...
7.
Li J, Huang J, Pang T, Chen Z, Li J, Wu L, et al.
Front Neurol
. 2021 Dec;
12:710144.
PMID: 34956037
Infections after acute ischemic stroke are common and likely to complicate the clinical course and negatively affect patient outcomes. Despite the development of various risk factors and predictive models for...
8.
Yan X, Yang Y, Chen Z, Yin Z, Deng Z, Qiu T, et al.
Aging (Albany NY)
. 2020 Nov;
12(21):21504-21517.
PMID: 33173014
Though promising, identifying synergistic combinations from a large pool of candidate drugs remains challenging for cancer treatment. Due to unclear mechanism and limited confirmed cases, only a few computational algorithms...
9.
Chen Z, Wang X, Li Y, Wang Y, Tang K, Wu D, et al.
Front Pharmacol
. 2019 Dec;
10:1353.
PMID: 31824313
Chronic liver disease (CLD) has become a major global health problem while herb prescriptions are clinically observed with significant efficacy. Three classical Traditional Chinese Medicine (TCM) formulae, Yinchenhao Decoction (YCHT),...
10.
Zhou C, Chen Z, Zhang L, Yan D, Mao T, Tang K, et al.
Nucleic Acids Res
. 2019 May;
47(W1):W388-W394.
PMID: 31114919
B-cell epitope information is critical to immune therapy and vaccine design. Protein epitopes can be significantly affected by glycosylation, while no methods have considered this till now. Based on previous...