Zhuo-Kun Chen
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Explore the profile of Zhuo-Kun Chen including associated specialties, affiliations and a list of published articles.
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5
Citations
37
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0
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Recent Articles
1.
Zhang H, Zhu L, Xie Q, Zhang L, Liu J, Feng Y, et al.
Cell Rep
. 2024 Nov;
43(11):114903.
PMID: 39489940
Malignancies can compromise systemic innate immunity, but the underlying mechanisms are largely unknown. Here, we find that tumor-derived small extracellular vesicles (sEVs; TEVs) deliver PD-L1 to host macrophages, thereby impeding...
2.
Chen Z, Zheng S, Long Y, Wang K, Xiao B, Li J, et al.
Mol Ther
. 2024 Sep;
32(10):3580-3596.
PMID: 39217416
Programmed death-ligand 1 (PD-L1) on tumor-derived small extracellular vesicles (sEVs) limits therapeutic effectiveness by interacting with the PD-1 receptor on host immune cells. Targeting the secretion of sEV PD-L1 has...
3.
Xiao B, Wang X, Xia H, Zhang L, Wang K, Chen Z, et al.
Cancer Immunol Res
. 2022 Dec;
11(2):228-240.
PMID: 36484721
PD-L1 localized to immunosuppressive small extracellular vesicles (sEV PD-L1) contributes to tumor progression and is associated with resistance to immune-checkpoint blockade (ICB) therapy. Here, by establishing a screening strategy with...
4.
Li Y, Chen Z, Duan X, Zhang H, Xiao B, Wang K, et al.
Exp Mol Med
. 2022 Sep;
54(9):1379-1389.
PMID: 36117219
Mounting evidence indicates that tumor-derived exosomes (TDEs) play critical roles in tumor development and progression by regulating components in the tumor microenvironment (TME) in an autocrine or paracrine manner. Moreover,...
5.
Yu Z, Zhao Y, Miao F, Wu M, Xia H, Chen Z, et al.
Anal Chem
. 2021 Jul;
93(31):10862-10870.
PMID: 34328732
Circulating small extracellular vesicles (sEVs) are naturally occurring nanosized membrane vesicles that convey bioactive molecules between cells. Conventionally, to evaluate their behaviors in vivo, circulating sEVs have to be isolated...