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Zhoubin Tian

Explore the profile of Zhoubin Tian including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 28
Followers 0
Related Specialties
Pharmacology
General Medicine
Biochemistry
Top 10 Co-Authors
Shui Sun
Ziling Gong
Qing Su
Baolin Xu
Laibo Zhang
Peng Jiang
Guang Yang
Siying Li
Wei Li
Bin Li
Published In
Biosci Rep
Chem Biol Drug Des
Biomed Res Int
Iran J Basic Med Sci
Pharmazie
Affiliations
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Recent Articles
1.
Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents inhibition of PI3K/Akt/mTOR signalling pathway
Su Q, Xu B, Tian Z, Gong Z
Acta Pharm . 2023 Jan; 72(3):389-402. PMID: 36651540
Osteosarcoma (OS) is an uncommon tumour that mainly affects bone in children and adolescents. The current treatment options of OS are of limited significance due to their immense side effects....
2.
1,3,5-triazines inhibit osteosarcoma and avert lung metastasis in a patient-derived orthotopic xenograft mouse model with favorable pharmacokinetics
Su Q, Xu B, Tian Z, Gong Z
Iran J Basic Med Sci . 2022 Jun; 25(3):295-301. PMID: 35656180
Objectives: Osteosarcoma is a major solid malignant tumor of bone, possessing significant burden on healthcare due to non-availability of specific anticancer agents. The current study was conducted to identify novel...
3.
Novel 1,3,5-triazine-nicotinohydrazide derivatives induce cell arrest and apoptosis in osteosarcoma cancer cells and inhibit osteosarcoma in a patient-derived orthotopic xenograft mouse model
Su Q, Xu B, Tian Z, Gong Z
Chem Biol Drug Des . 2021 Nov; 99(2):320-330. PMID: 34811888
The present study deals with developing novel 1,3,5-triazine-nicotinohydrazide derivatives as potent CDK9 inhibitors in a straightforward synthetic route with potent anti-osteosarcoma activity. The most potent CDK9 inhibitor compound 5k inhibits...
4.
Long non-coding RNA Sox4 promotes proliferation and migration by activating Wnt/β-catenin signaling pathway in osteosarcoma
Tian Z, Yang G, Jiang P, Zhang L, Wang J, Sun S
Pharmazie . 2018 Feb; 72(9):537-542. PMID: 29441981
Osteosarcoma is a bone tumor without effective treatment in the world. Recently, long non-coding RNAs (lncRNAs) are considered as essential regulators in cancer progression. LncSox4 plays crucial roles in liver...
5.
Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-B Pathway
Yang G, Li S, Li B, Cheng L, Jiang P, Tian Z, et al.
Biomed Res Int . 2018 Jan; 2017:8686207. PMID: 29333456
Background: Garlic-derived S-allylmercaptocysteine (SAMC) has widely been used in many disease therapies. However, the potential effects and mechanism of SAMC on IL-1-stimulated chondrocytes are unclear. Methods: Chondrocytes were isolated, and...
6.
Inhibitory effect of quercetin on titanium particle-induced endoplasmic reticulum stress (ERS)-related apoptosis and osteolysis
Zhang L, Tian Z, Li W, Wang X, Man Z, Sun S
Biosci Rep . 2017 Aug; 37(4). PMID: 28760844
Wear particle-induced periprosthetic osteolysis is the main cause of aseptic loosening of orthopaedic implants. The aim of this study is to determine the protective effect of quercetin (QUE) against titanium...