Zhitai Hao
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Explore the profile of Zhitai Hao including associated specialties, affiliations and a list of published articles.
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10
Citations
125
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0
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Recent Articles
1.
Yang K, Cameranesi M, Gowder M, Martinez C, Shamovsky Y, Epshtein V, et al.
Nature
. 2023 Aug;
622(7981):180-187.
PMID: 37648864
Antibiotic binding sites are located in important domains of essential enzymes and have been extensively studied in the context of resistance mutations; however, their study is limited by positive selection....
2.
Sun Y, Huang Y, Hao Z, Zhang S, Tian Q
Cell Prolif
. 2023 Jun;
57(1):e13524.
PMID: 37357415
Adult stem cells (ASCs) are pluripotent cells with the capacity to self-renew and constantly replace lost cells due to physiological turnover or injury. Understanding the molecular mechanisms of the precise...
3.
Hao Z, Gowder M, Proshkin S, Bharati B, Epshtein V, Svetlov V, et al.
Cell
. 2023 May;
186(11):2425-2437.e21.
PMID: 37196657
Ribonuclease HII (RNaseHII) is the principal enzyme that removes misincorporated ribonucleoside monophosphates (rNMPs) from genomic DNA. Here, we present structural, biochemical, and genetic evidence demonstrating that ribonucleotide excision repair (RER)...
4.
Hao Z, Svetlov V, Nudler E
Transcription
. 2021 Oct;
12(4):171-181.
PMID: 34705601
Rho is a hexameric bacterial RNA helicase, which became a paradigm of factor-dependent transcription termination. The broadly accepted ("textbook") model posits a series of steps, wherein Rho first binds C-rich...
5.
Rasouly A, Shamovsky Y, Epshtein V, Tam K, Vasilyev N, Hao Z, et al.
Nat Microbiol
. 2021 Oct;
6(11):1410-1423.
PMID: 34697460
Mutations in the rifampicin (Rif)-binding site of RNA polymerase (RNAP) confer antibiotic resistance and often have global effects on transcription that compromise fitness and stress tolerance of resistant mutants. We...
6.
Tian Q, Sun Y, Gao T, Li J, Hao Z, Fang H, et al.
J Cell Biochem
. 2021 Feb;
122(7):731-738.
PMID: 33586232
The molecular mechanisms responsible for axis establishment during non-embryonic processes remain elusive. The planarian flatworm is an ideal model organism to study body axis polarization and patterning in vivo. Here,...
7.
Ge C, Lin C, Zhang M, Yuan J, Feng X, Hao Z, et al.
Gene
. 2021 Jan;
775:145440.
PMID: 33482282
Tubgcp3/GCP3 (The centrosomal protein γ-tubulin complex protein 3) is a component of the γ-tubulin small complexes (γ-TuSCs) and γ-tubulin ring complexes (γ-TuRCs), which play critical roles in mitotic spindle formation...
8.
Hao Z, Epshtein V, Kim K, Proshkin S, Svetlov V, Kamarthapu V, et al.
Mol Cell
. 2020 Dec;
81(2):281-292.e8.
PMID: 33296676
Rho is a general transcription termination factor playing essential roles in RNA polymerase (RNAP) recycling, gene regulation, and genomic stability in most bacteria. Traditional models of transcription termination postulate that...
9.
Zhang Z, Hao Z, Wang Z, Li Q, Xie W
Acta Crystallogr D Biol Crystallogr
. 2014 Sep;
70(Pt 9):2286-94.
PMID: 25195743
The 6-aminopurine ring of adenosine (A) can be deaminated to form the 6-oxopurine of inosine (I). Endonuclease Vs (EndoVs) are inosine-specific nucleases that cleave at the second phosphodiester bond 3'...
10.
Qin X, Hao Z, Tian Q, Zhang Z, Zhou C, Xie W
J Biol Chem
. 2014 Jun;
289(29):20359-69.
PMID: 24898252
Aminoacyl-tRNA synthetases are an ancient enzyme family that specifically charges tRNA molecules with cognate amino acids for protein synthesis. Glycyl-tRNA synthetase (GlyRS) is one of the most intriguing aminoacyl-tRNA synthetases...