Zhi-Nan Chen
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Explore the profile of Zhi-Nan Chen including associated specialties, affiliations and a list of published articles.
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217
Citations
5287
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Recent Articles
1.
Qin Y, Huo F, Feng Z, Hou J, Ding Y, Wang Q, et al.
Clin Mol Hepatol
. 2025 Mar;
PMID: 40037690
Background: The identification of factors that lead to CD8⁺ T cell dysfunction within the tumor microenvironment (TME) holds great promise for the development of innovative immunotherapies. However, the precise mechanisms...
2.
Yang Z, Han T, Yang R, Zhang Y, Qin Y, Hou J, et al.
Front Immunol
. 2025 Feb;
16:1531874.
PMID: 40007539
Introduction: Ferroptosis, an iron-dependent form of regulated cell death, is characterized by the lethal accumulation of lipid peroxides on cellular membranes. It not only inhibits tumor growth but also enhances...
3.
Huang W, Zhong L, Shi Y, Ma Q, Yang X, Zhang H, et al.
Adv Sci (Weinh)
. 2025 Feb;
:e2410438.
PMID: 39985225
Effective treatment strategies are urgently needed for hepatocellular carcinoma (HCC) patients due to frequent therapeutic resistance and recurrence. Antibody-drug conjugate (ADC) is a specific antibody-drug conjugated with small molecular compounds,...
4.
Zhang Y, Chen X, Chen R, Li L, Ju Q, Qiu D, et al.
Clin Transl Med
. 2025 Jan;
15(1):e70170.
PMID: 39794303
Background: Gut microbiome on predicting clinical responses to immune checkpoint inhibitors (ICIs) has been discussed in detail for decades, while microecological features of the lower respiratory tract within advanced non-small-cell...
5.
Wang S, Chao D, Wei W, Nan G, Li J, Liu F, et al.
J Exp Clin Cancer Res
. 2024 Dec;
43(1):320.
PMID: 39676170
No abstract available.
6.
Feng L, Chen Z, Bian H
MedComm (2020)
. 2024 Jul;
5(7):e649.
PMID: 38988494
Skeletal muscle is an important motor organ with multinucleated myofibers as its smallest cellular units. Myofibers are formed after undergoing cell differentiation, cell-cell fusion, myonuclei migration, and myofibril crosslinking among...
7.
Wang K, Chen X, Lin P, Wu J, Huang Q, Chen Z, et al.
Adv Sci (Weinh)
. 2024 Jun;
11(29):e2400611.
PMID: 38873823
Immunosuppression is a major hallmark of tumor progression in non-small cell lung cancer (NSCLC). Cluster of differentiation 147 (CD147), an important pro-tumorigenic factor, is closely linked to NSCLC immunosuppression. However,...
8.
Qi F, Su H, Wang B, Qian L, Wang Y, Wang C, et al.
MedComm (2020)
. 2024 Mar;
5(3):e512.
PMID: 38469549
Therapeutic antibodies (Abs) improve the clinical outcome of cancer patients. However, on-target off-tumor toxicity limits Ab-based therapeutics. Cluster of differentiation 147 (CD147) is a tumor-associated membrane antigen overexpressed in cancer...
9.
Lv J, Wang H, Zhang C, Zhang T, Wei H, Liu Z, et al.
Circ Res
. 2024 Jan;
134(2):165-185.
PMID: 38166463
Background: Atherosclerosis is a globally prevalent chronic inflammatory disease with high morbidity and mortality. The development of atherosclerotic lesions is determined by macrophages. This study aimed to investigate the specific...
10.
Zhang J, Song C, Wang M, Zhang G, Wang B, Chen X, et al.
J Pharm Anal
. 2023 Nov;
13(10):1135-1152.
PMID: 38024852
Morphine is a frequently used analgesic that activates the mu-opioid receptor (MOR), which has prominent side effects of tolerance. Although the inefficiency of morphine in inducing the endocytosis of MOR...