Zhengkai Chen
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Explore the profile of Zhengkai Chen including associated specialties, affiliations and a list of published articles.
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41
Citations
116
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Recent Articles
1.
Li C, Zhang Y, Chen Z
J Org Chem
. 2025 Mar;
90(10):3796-3804.
PMID: 40036747
A catalyst and additive-free [2+1] annulation of 3-alkenyl-oxindoles with CF-imidoyl sulfoxonium ylides (TFISYs) for the construction of spiro 3,3'-cyclopropyl oxindoles has been achieved. A cascade intermolecular Micheal-addition reaction and intramolecular...
2.
Li P, Yang Z, Chen Z
J Org Chem
. 2024 Jul;
89(15):10736-10747.
PMID: 39021230
A rhodium(III)-catalyzed aldehydic C(sp)-H imidoylmethylation of quinolin-8-carboxaldehydes with CF-imidoyl sulfoxonium ylides (TFISYs) has been developed for the generation of α-imino ketones, which could be readily tautomerized to enaminones in moderate...
3.
Wei G, Zheng D, Li C, Chen Z, Wu X
Org Lett
. 2023 Sep;
25(38):7046-7050.
PMID: 37721372
A base-mediated cascade reaction of CF-imidoyl sulfoxonium ylides and azo compounds has been achieved, allowing for facile access to trifluoromethyl-substituted 1,2-dihydroquinoxalines and diimines in moderate to excellent yields. Noteworthy is...
4.
Song Y, Quan Z, Chen Z, Wu X
Org Lett
. 2023 May;
25(21):3984-3988.
PMID: 37222365
A facile and straightforward approach for the synthesis of fused quinoxalinones via palladium-catalyzed cascade carbonylative cyclization of 2-heteroaryl iodobenzene and NaN has been achieved. The transformation might undergo cascade carbonylation,...
5.
Yang Z, Wei G, Chen Z, Wu X
Chem Commun (Camb)
. 2023 Mar;
59(33):4872-4890.
PMID: 37000709
Recent advances in the direct synthesis of trifluoromethyl-containing heterocycles from trifluoroacetimidoyl chlorides (TFAICs) and derivatives, including trifluoroacetimidohydrazides (TFAIHs) and CF-imidoyl sulfoxonium ylides (TFISYs), are systematically summarized and discussed. The cascade...
6.
Yang Z, Tang J, Li C, Chen Z, Wu X
Chem Commun (Camb)
. 2022 Dec;
59(3):318-321.
PMID: 36511166
A rhodium(III)-catalyzed regioselective C2-alkenylation of indoles for the construction of α-CF substituted enamines has been developed, which utilizes CF-imidoyl sulfoxonium ylides (TFISYs) as alkenylating agents for the first time. A...
7.
Wei G, Zhang J, Wang H, Chen Z, Wu X
Org Biomol Chem
. 2022 Dec;
21(2):284-288.
PMID: 36484764
A radical selenylative cyclization of trifluoromethyl propargyl imines with diselenides for the regiodivergent construction of diversely functionalized azaspiro[4,5]-tetraenones and quinolines has been developed, which enables dual incorporation of CF and...
8.
Zhang Y, Ling S, Li P, Chen Z, Wu X
Org Lett
. 2022 Dec;
24(48):8864-8869.
PMID: 36453537
An efficient and straightforward approach for the synthesis of trifluoromethyl-decorated benzo[][1,8]naphthyridines has been achieved via the Rh(III)-catalyzed dual C-H activation and cascade annulation of benzimidates and CF-imidoyl sulfoxonium ylides. The...
9.
Wang B, Sun Y, Cheng A, Zhu Y, Wang J, Chen Z, et al.
Front Chem
. 2022 Oct;
10:1013977.
PMID: 36204143
A convenient approach for the construction of pharmaceutically valuable 3-trifluoromethyl-1,2,4-triazoles has been developed, which employs the readily available trifluoroacetimidoyl chlorides, hydrazine hydrate and benzene-1,3,5-triyl triformate (TFBen) as starting materials. The...
10.
Yang Z, Tang J, Chen Z, Wu X
Org Lett
. 2022 Oct;
24(40):7288-7293.
PMID: 36194465
A ruthenium-catalyzed -selective C-H activation and annulation of 1-naphthols with CF-substituted imidoyl sulfoxonium ylides that uses hydroxyl as a weakly coordinating directing group is disclosed. The strategy provides a facile...