Zhe-Chong Wang
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Explore the profile of Zhe-Chong Wang including associated specialties, affiliations and a list of published articles.
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13
Citations
89
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Recent Articles
1.
Wang Y, Chang C, Hsu N, Lo I, Lin K, Chen C, et al.
Nat Commun
. 2023 May;
14(1):2528.
PMID: 37137912
Oxidized cysteine residues are highly reactive and can form functional covalent conjugates, of which the allosteric redox switch formed by the lysine-cysteine NOS bridge is an example. Here, we report...
2.
Kuo C, Lin W, Liu C, Wang Z, Liu T, Peng H
J Microbiol Immunol Infect
. 2023 Mar;
56(3):464-476.
PMID: 36898943
Background: CpxAR is a two-component system that allows bacteria to reorganize envelope structures in response to extracellular stimuli. CpxAR negatively affects type 1 fimbriae expression in Klebsiella pneumoniae CG43, a...
3.
Zadeh S, Chen M, Wang Z, Astani E, Lo I, Lin K, et al.
Commun Chem
. 2023 Jan;
5(1):87.
PMID: 36697788
Caprazamycin is a nucleoside antibiotic that inhibits phospho-N-acetylmuramyl-pentapeptide translocase (MraY). The biosynthesis of nucleoside antibiotics has been studied but is still far from completion. The present study characterized enzymes Cpz10,...
4.
Wang Z, Lo I, Lin K, Cheng A, Zadeh S, Huang Y, et al.
Appl Environ Microbiol
. 2022 Aug;
88(17):e0080622.
PMID: 36000868
Albofungin, a hexacyclic aromatic natural product, exhibits broad-spectrum antimicrobial activity. Its biosynthesis, regulation, and resistance remain elusive. Here, we report the albofungin () biosynthetic gene cluster (BGC) from its producing...
5.
Rattinam R, Basha R, Wang Y, Wang Z, Hsu N, Lin K, et al.
Biomedicines
. 2022 Feb;
10(2).
PMID: 35203422
Kasugamycin (KSM), an aminoglycoside antibiotic, is composed of three chemical moieties: D--inositol, kasugamine and glycine imine. Despite being discovered more than 50 years ago, the biosynthetic pathway of KSM remains...
6.
Wang T, Wu R, Hong Y, Wang Z, Li T, Shie J, et al.
Chembiochem
. 2021 Apr;
22(14):2415-2419.
PMID: 33915022
Secondary metabolites are structurally diverse natural products (NPs) and have been widely used for medical applications. Developing new tools to enrich NPs can be a promising solution to isolate novel...
7.
Zadeh S, Astani E, Wang Z, Adhikari K, Rattinam R, Li T
ACS Omega
. 2020 Sep;
5(36):22739-22749.
PMID: 32954121
Phospho--acetylmuramoyl-pentapeptide translocase (MraY) from is the binding target for the nucleotide antibiotic muraymycin D2 (MD2). MraY in the presence of the MD2 ligand has been crystallized and released, while the...
8.
Lin K, Lyu S, Yeh H, Li Y, Hsu N, Huang C, et al.
Protein Sci
. 2020 May;
29(7):1655-1666.
PMID: 32362037
Though reactive flavin-N5/C4α-oxide intermediates can be spectroscopically profiled for some flavin-assisted enzymatic reactions, their exact chemical configurations are hardly visualized. Structural systems biology and stable isotopic labelling techniques were exploited...
9.
Wang Z, Liu C, Huang Y, Wang Y, Peng H
Microbiology (Reading)
. 2015 Sep;
161(12):2395-409.
PMID: 26385366
In the Klebsiella pneumoniae CG43 genome, the divergently transcribed genes coding for PecS, the MarR-type transcription factor, and PecM, the drug metabolite transporter, are located between the type 1 and...
10.
Huang C, Wang Z, Huang H, Huang H, Peng H
PLoS One
. 2013 Aug;
8(7):e66740.
PMID: 23935824
This study shows that the expression of yjcC, an in vivo expression (IVE) gene, and the stress response regulatory genes soxR, soxS, and rpoS are paraquat inducible in Klebsiella pneumoniae...