Tsung-Lin Li
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Explore the profile of Tsung-Lin Li including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Selvaraj S, Lin K, Lin W, You M, Li T, Chen J
ACS Omega
. 2024 Jul;
9(27):29756-29764.
PMID: 39005813
Gram-negative pathogens that produce β-lactamases pose a serious public health threat as they can render β-lactam antibiotics inactive via hydrolysis. This action contributes to the waning effectiveness of clinical antibiotics...
2.
Liu S, Huang H, Lo I, Lin Y, Liao G, Chao C, et al.
Bioorg Chem
. 2023 Sep;
141:106843.
PMID: 37696148
In the present study, the undescribed schitriterpenoids, kadsujanonols A-I (1-9), and eleven reported compounds (10-20) were isolated from K. japonica L. vines. Their structures of 3,4-seco-schitriterpenoids were elucidated mainly by...
3.
Chang S, Huang H, Wei W, Lo I, Lin Y, Chao C, et al.
Front Chem
. 2023 Jul;
11:1223335.
PMID: 37426336
The Euphorbiaceae plant L. is distributed widely in India, Thailand, Southeastern China, and Taiwan and used as a carminative and expectorant to treat several inflammation-related diseases, such as gonorrhoea, asthma,...
4.
Wang Y, Chang C, Hsu N, Lo I, Lin K, Chen C, et al.
Nat Commun
. 2023 May;
14(1):2528.
PMID: 37137912
Oxidized cysteine residues are highly reactive and can form functional covalent conjugates, of which the allosteric redox switch formed by the lysine-cysteine NOS bridge is an example. Here, we report...
5.
Zadeh S, Chen M, Wang Z, Astani E, Lo I, Lin K, et al.
Commun Chem
. 2023 Jan;
5(1):87.
PMID: 36697788
Caprazamycin is a nucleoside antibiotic that inhibits phospho-N-acetylmuramyl-pentapeptide translocase (MraY). The biosynthesis of nucleoside antibiotics has been studied but is still far from completion. The present study characterized enzymes Cpz10,...
6.
Huang H, Lo I, Lin Y, Geng-You L, Lin Y, Zhang L, et al.
Nat Prod Res
. 2023 Jan;
38(13):2179-2186.
PMID: 36606546
The spirohydantoin-containing cucurbitane-type triterpenoid, kaguacidine A (), was isolated and purified from 95% ethanol extract of vines of L. (Cucurbitaceae). Its unprecedented chemical structure, a spirohydantoin substituent at C-23 of...
7.
Lo I, Liao G, Lee J, Chang C, Wu Y, Chen Y, et al.
Pharmaceuticals (Basel)
. 2022 Oct;
15(10).
PMID: 36297330
Hybrid natural products produced via mixed biosynthetic pathways are unique and often surprise one with unexpected medicinal properties in addition to their fascinating structural complexity/diversity. In view of chemical structures,...
8.
Huang H, Lo I, Liao G, Lin Y, Shen Y, Huang H, et al.
Front Chem
. 2022 Oct;
10:1003356.
PMID: 36186589
Hemsley is a plant conventionally processed to provide popular food materials and herbal medicines in Asia. In this study, six triterpene acids, including five new ones (mesonaic acids D-H, -),...
9.
Astani E, Zadeh S, Hsu N, Lin K, Sardari S, Li T
ACS Omega
. 2022 Sep;
7(37):32970-32987.
PMID: 36157785
Tunicamycin (TUN) is a nucleoside antibiotic with a complex structure comprising uracil, tunicamine sugar, -acetylglucosamine (GlcNAc), and fatty acyl tail moieties. TUN, known as a canonical inhibitor, blocks vital functions...
10.
Wang Z, Lo I, Lin K, Cheng A, Zadeh S, Huang Y, et al.
Appl Environ Microbiol
. 2022 Aug;
88(17):e0080622.
PMID: 36000868
Albofungin, a hexacyclic aromatic natural product, exhibits broad-spectrum antimicrobial activity. Its biosynthesis, regulation, and resistance remain elusive. Here, we report the albofungin () biosynthetic gene cluster (BGC) from its producing...