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Zhaozhao Ding

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Articles 39
Citations 423
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Recent Articles
1.
Fan Z, Liu H, Ding Z, Xiao L, Lu Q, Kaplan D
Adv Funct Mater . 2023 Aug; 33(33). PMID: 37601745
Different tissues have complex anisotropic structures to support biological functions. Mimicking these complex structures remains a challenge in biomaterials designs in support of tissue regeneration. Here, inspired by different types...
2.
Ding Z, Cheng W, Liu L, Xu G, Lu Q, Kaplan D
Adv Healthc Mater . 2023 Jun; 12(26):e2300887. PMID: 37317936
Metal ions provide multifunctional signals for cell and tissue functions, including regeneration. Inspired by metal-organic frameworks (MOFs), nanosized silk protein aggregates with a high negative charge density are used to...
3.
Hou J, Ding Z, Zheng X, Shen Y, Lu Q, Kaplan D
Adv Healthc Mater . 2023 Feb; 12(17):e2203050. PMID: 36841910
Tough porous cryogels with angiogenesis and osteogenesis features remain a design challenge for utility in bone regeneration. Here, building off of the recent efforts to generate tough silk nanofiber-derived cryogels...
4.
Fan Z, Liu H, Shi S, Ding Z, Zhang Z, Lu Q, et al.
Mater Today Bio . 2022 May; 15:100283. PMID: 35634170
Osteogenesis-angiogenesis coupling processes play a crucial role in bone regeneration. Here, electric field induced aligned nanofiber layers with tunable thickness were coated on the surface of pore walls inside the...
5.
Zhang X, Xiao L, Ding Z, Lu Q, Kaplan D
ACS Nano . 2022 May; 16(7):10209-10218. PMID: 35587205
β-Sheet rich silk nanofiber hydrogels are suitable scaffolds in tissue regeneration and carriers for various drugs. However, unsatisfactory mechanical performance limits its applications. Here, insight into the silk nanofibers stimulates...
6.
Zhang X, Hang Y, Ding Z, Xiao L, Cheng W, Lu Q
Biomacromolecules . 2022 Apr; 23(5):2160-2169. PMID: 35443774
Cryogels are widely used in tissue regeneration due to their porous structures and friendly hydrogel performance. Silk-based cryogels were developed but failed to exhibit desirable tunable properties to adapt various...
7.
Lu X, Ding Z, Xu F, Lu Q, Kaplan D
ACS Appl Bio Mater . 2022 Jan; 2(7):3108-3119. PMID: 35030802
The rigidity of extracellular matrices can impact cell fate, guide tissue development, and initiate tumor formation. Scaffolds such as hydrogels with tunable levels of stiffness have been developed to control...
8.
Li M, Zhong L, He W, Ding Z, Hou Q, Zhao Y, et al.
ACS Appl Bio Mater . 2022 Jan; 2(10):4397-4407. PMID: 35021399
An injectable hydrogel is a powerful carrier for therapeutic bioactive molecules. Here, an injected concentrated conditioned medium (CCM)-silk nanofiber composite hydrogel was developed to achieve the sustained release of multiple...
9.
Gao X, Cheng W, Zhang X, Zhou Z, Ding Z, Zhou X, et al.
ACS Appl Mater Interfaces . 2022 Jan; 14(3):3701-3715. PMID: 35006667
Scarless spinal cord regeneration remains a challenge due to the complicated microenvironment at lesion sites. In this study, the nerve growth factor (NGF) was immobilized in silk protein nanofiber hydrogels...
10.
Xiao L, Ding Z, Zhang X, Wang X, Lu Q, Kaplan D
ACS Biomater Sci Eng . 2021 Dec; 8(1):140-150. PMID: 34878245
Silk nanofibers are versatile carriers for hydrophobic and hydrophilic drugs, but fall short in terms of effective delivery to cells, which is essential for therapeutic benefits. Here, the size of...