Zhaokai Yao
Overview
Explore the profile of Zhaokai Yao including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
278
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0
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Recent Articles
1.
Huang Y, Li L, An G, Yang X, Cui M, Song X, et al.
Nat Cell Biol
. 2023 Sep;
25(10):1520-1534.
PMID: 37723297
Human spermatogenesis is a highly ordered process; however, the roles of DNA methylation and chromatin accessibility in this process remain largely unknown. Here by simultaneously investigating the chromatin accessibility, DNA...
2.
Li C, Yao Z, Ma L, Song X, Wang W, Wan C, et al.
Stem Cell Reports
. 2023 Apr;
18(4):969-984.
PMID: 37044069
The spermatogonial stem cell (SSC) niche is critical for SSC maintenance and subsequent spermatogenesis. Numerous reproductive hazards impair the SSC niche, thereby resulting in aberrant SSC self-renewal and male infertility....
3.
Lin Z, Liang P, Yao Z, Chen Y, Zhang X, Huang R, et al.
Sci Bull (Beijing)
. 2023 Jan;
64(8):524-533.
PMID: 36659742
Mammalian spermatogenesis is maintained by a rare population of spermatogonial stem cells (SSCs), which are important for male fertility. SSCs remain a subset of undifferentiated spermatogonia, which can be isolated...
4.
Yu S, Zhou C, He J, Yao Z, Huang X, Rong B, et al.
Nat Commun
. 2022 May;
13(1):2756.
PMID: 35589713
Multiple pluripotent states have been described in mouse and human stem cells. Here, we apply single-cell RNA-seq to a newly established BMP4 induced mouse primed to naïve transition (BiPNT) system...
5.
Zhao J, Lu P, Wan C, Huang Y, Cui M, Yang X, et al.
Nat Commun
. 2021 Nov;
12(1):6839.
PMID: 34824237
Mammalian male germ cell development is a stepwise cell-fate transition process; however, the full-term developmental profile of male germ cells remains undefined. Here, by interrogating the high-precision transcriptome atlas of...
6.
Wang X, Veerapandian V, Yang X, Song K, Xu X, Cui M, et al.
Stem Cell Reports
. 2021 Apr;
16(5):1245-1261.
PMID: 33930315
In vitro induction of human primordial germ cell-like cells (hPGCLCs) provides an ideal platform to recapitulate hPGC development. However, the detailed molecular mechanisms regulating the induction of hPGCLCs remain largely...
7.
Yuan W, Yao Z, Veerapandian V, Yang X, Wang X, Chen D, et al.
Int J Biol Sci
. 2021 Feb;
17(2):527-538.
PMID: 33613110
Germline specification is a fundamental step for human reproduction and this biological phenomenon possesses technical challenges to study as it occurs immediately after blastocyst implantation. The establishment of human primordial...
8.
Wang X, Liao T, Wan C, Yang X, Zhao J, Fu R, et al.
PeerJ
. 2019 Jan;
6:e6143.
PMID: 30643676
Background: The mechanisms underlying human germ cell development and infertility remain largely unknown due to bioethical issues and the shortage of experimental materials. Therefore, an effective in vitro induction system...
9.
Wang M, Liu X, Chang G, Chen Y, An G, Yan L, et al.
Cell Stem Cell
. 2018 Sep;
23(4):599-614.e4.
PMID: 30174296
Spermatogenesis generates mature male gametes and is critical for the proper transmission of genetic information between generations. However, the developmental landscapes of human spermatogenesis remain unknown. Here, we performed single-cell...