Zehava Eichenbaum
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Explore the profile of Zehava Eichenbaum including associated specialties, affiliations and a list of published articles.
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30
Citations
482
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Recent Articles
1.
Womack E, Antone M, Eichenbaum Z
Microbiol Spectr
. 2024 Oct;
:e0133124.
PMID: 39470285
Importance: obtains growth essential iron from hemoglobin and other host hemoproteins. Still, the bacterial mechanisms involved are only partially understood, and there are inconsistent reports regarding the function of several...
2.
Womack E, Alibayov B, Vidal J, Eichenbaum Z
Microbiol Spectr
. 2023 Dec;
12(1):e0329723.
PMID: 38038454
Heme degradation provides pathogens with growth essential iron, leveraging on the host heme reservoir. Bacteria typically import and degrade heme enzymatically, and here, we demonstrated a significant deviation from this...
3.
Yu B, Roy Choudhury M, Yang X, Benoit S, Womack E, Lyles K, et al.
ACS Infect Dis
. 2022 Jul;
8(8):1491-1508.
PMID: 35801980
The rapid and persistent emergence of drug-resistant bacteria poses a looming public health crisis. The possible task of developing new sets of antibiotics to replenish the existing ones is daunting...
4.
Lyles K, Thomas L, Ouellette C, Cook L, Eichenbaum Z
Front Cell Infect Microbiol
. 2022 Jul;
12:867963.
PMID: 35774404
Group A Streptococcus (GAS) is a major pathogen that causes simple and invasive infections. GAS requires iron for metabolic processes and pathogenesis, and heme is its preferred iron source. We...
5.
Traore E, Li J, Chiura T, Geng J, Sachla A, Yoshimoto F, et al.
Molecules
. 2021 Jan;
26(3).
PMID: 33494451
HupZ is an expected heme degrading enzyme in the heme acquisition and utilization pathway in Group A Streptococcus. The isolated HupZ protein containing a C-terminal V5-His tag exhibits a weak...
6.
Akhter F, Womack E, Vidal J, Le Breton Y, McIver K, Pawar S, et al.
Infect Immun
. 2021 Jan;
89(4).
PMID: 33397818
grows in biofilms during both asymptomatic colonization and infection. Pneumococcal biofilms on abiotic surfaces exhibit delayed growth and lower biomass and lack the structures seen on epithelial cells or during...
7.
McDevitt E, Khan F, Scasny A, Thompson C, Eichenbaum Z, McDaniel L, et al.
mSphere
. 2020 Dec;
5(6).
PMID: 33298575
and other streptococci produce a greenish halo on blood agar plates referred to as alpha-hemolysis. This phenotype is utilized by clinical microbiology laboratories to report culture findings of alpha-hemolytic streptococci,...
8.
Hopper C, De La Cruz L, Lyles K, Wareham L, Gilbert J, Eichenbaum Z, et al.
Chem Rev
. 2020 Oct;
120(24):13273-13311.
PMID: 33089988
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between host and mutualistic bacteria is attracting increasing attention to the degree that the gut microbiome is proposed...
9.
Akhter F, Womack E, Vidal J, Le Breton Y, McIver K, Pawar S, et al.
Sci Rep
. 2020 Sep;
10(1):15202.
PMID: 32938947
Streptococcus pneumoniae (Spn) must acquire iron from the host to establish infection. We examined the impact of hemoglobin, the largest iron reservoir in the body, on pneumococcal physiology. Supplementation with...
10.
Chatterjee N, Huang Y, Lyles K, Morgan J, Kauvar L, Greer S, et al.
J Infect Dis
. 2020 Aug;
223(8):1367-1375.
PMID: 32845315
Background: A vaccine against group A Streptococcus (GAS) has been actively pursued for decades. The surface receptor Shr is vital in GAS heme uptake and provides an effective target for...