Zachary Gardner
Overview
Explore the profile of Zachary Gardner including associated specialties, affiliations and a list of published articles.
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4
Citations
385
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Recent Articles
1.
Yu R, Roseman S, Siegenfeld A, Gardner Z, Nguyen S, Tran K, et al.
Nat Struct Mol Biol
. 2025 Feb;
PMID: 39984730
Recent findings indicate that nuclear speckles, a distinct type of nuclear body, interact with certain chromatin regions in a ground state. Here, we report that the chromatin structural factors CTCF...
2.
Alexanian M, Padmanabhan A, Nishino T, Travers J, Ye L, Pelonero A, et al.
Nature
. 2024 Oct;
635(8038):434-443.
PMID: 39443808
Chronic inflammation and tissue fibrosis are common responses that worsen organ function, yet the molecular mechanisms governing their cross-talk are poorly understood. In diseased organs, stress-induced gene expression changes fuel...
3.
Gardner Z, Holbrook O, Tian Y, Odamah K, Man H
Exp Neurol
. 2024 Mar;
376:114756.
PMID: 38508482
Overexpression of the Ube3a gene and the resulting increase in Ube3a protein are linked to autism spectrum disorder (ASD). However, the cellular and molecular processes underlying Ube3a-dependent ASD remain unclear....
4.
Schmid-Burgk J, Gao L, Li D, Gardner Z, Strecker J, Lash B, et al.
Mol Cell
. 2020 Mar;
78(4):794-800.e8.
PMID: 32187529
Determining the off-target cleavage profile of programmable nucleases is an important consideration for any genome editing experiment, and a number of Cas9 variants have been reported that improve specificity. We...
5.
Strecker J, Ladha A, Gardner Z, Schmid-Burgk J, Makarova K, Koonin E, et al.
Science
. 2019 Jun;
365(6448):48-53.
PMID: 31171706
CRISPR-Cas nucleases are powerful tools for manipulating nucleic acids; however, targeted insertion of DNA remains a challenge, as it requires host cell repair machinery. Here we characterize a CRISPR-associated transposase...