Zachary C Ruhe
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Explore the profile of Zachary C Ruhe including associated specialties, affiliations and a list of published articles.
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17
Citations
1259
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Recent Articles
1.
Jensen S, Ruhe Z, Williams A, Nhan D, Garza-Sanchez F, Low D, et al.
J Bacteriol
. 2023 May;
205(6):e0011323.
PMID: 37212679
Type VI secretion systems (T6SSs) deliver cytotoxic effector proteins into target bacteria and eukaryotic host cells. Antibacterial effectors are invariably encoded with cognate immunity proteins that protect the producing cell...
2.
Jensen S, Ruhe Z, Williams A, Nhan D, Garza-Sanchez F, Low D, et al.
bioRxiv
. 2023 Apr;
PMID: 37034769
Type VI secretion systems (T6SS) deliver cytotoxic effector proteins into target bacteria and eukaryotic host cells. Antibacterial effectors are invariably encoded with cognate immunity proteins that protect the producing cell...
3.
Halvorsen T, Garza-Sanchez F, Ruhe Z, Bartelli N, Chan N, Nguyen J, et al.
mBio
. 2021 Oct;
12(5):e0253021.
PMID: 34634941
Contact-dependent growth inhibition (CDI) systems enable the direct transfer of protein toxins between competing Gram-negative bacteria. CDI strains produce cell surface CdiA effector proteins that bind specific receptors on neighboring...
4.
Donato S, Beck C, Garza-Sanchez F, Jensen S, Ruhe Z, Cunningham D, et al.
Proc Natl Acad Sci U S A
. 2020 Dec;
117(52):33540-33548.
PMID: 33323487
Bacteria deploy rearrangement hotspot (Rhs) proteins as toxic effectors against both prokaryotic and eukaryotic target cells. Rhs proteins are characterized by YD-peptide repeats, which fold into a large β-cage structure...
5.
Ruhe Z, Low D, Hayes C
Annu Rev Microbiol
. 2020 Jul;
74:497-520.
PMID: 32680451
All bacteria must compete for growth niches and other limited environmental resources. These existential battles are waged at several levels, but one common strategy entails the transfer of growth-inhibitory protein...
6.
Ruhe Z, Subramanian P, Song K, Nguyen J, Stevens T, Low D, et al.
Cell
. 2018 Nov;
175(4):921-933.e14.
PMID: 30388452
Contact-dependent growth inhibition (CDI) entails receptor-mediated delivery of CdiA-derived toxins into Gram-negative target bacteria. Using electron cryotomography, we show that each CdiA effector protein forms a filament extending ∼33 nm...
7.
Ruhe Z, Nguyen J, Xiong J, Koskiniemi S, Beck C, Perkins B, et al.
mBio
. 2017 Mar;
8(2).
PMID: 28351921
Contact-dependent growth inhibition (CDI) systems encode CdiA effectors, which bind to specific receptors on neighboring bacteria and deliver C-terminal toxin domains to suppress target cell growth. Two classes of CdiA...
8.
Ruhe Z, Nguyen J, Chen A, Leung N, Hayes C, Low D
PLoS Genet
. 2016 Jun;
12(6):e1006145.
PMID: 27355474
Contact-dependent growth inhibition (CDI) systems are widespread amongst Gram-negative bacteria where they play important roles in inter-cellular competition and biofilm formation. CDI+ bacteria use cell-surface CdiA proteins to bind neighboring...
9.
Ruhe Z, Hayes C, Low D
Methods Mol Biol
. 2015 Oct;
1329:127-36.
PMID: 26427680
Cell-cell adhesion mediates a number of competitive and cooperative microbial interactions. Fluorescence labeling and flow cytometry techniques allow us to observe and measure these interactions rapidly and easily. Here, we...
10.
Willett J, Ruhe Z, Goulding C, Low D, Hayes C
J Mol Biol
. 2015 Sep;
427(23):3754-65.
PMID: 26388411
Bacteria have developed several strategies to communicate and compete with one another in complex environments. One important mechanism of inter-bacterial competition is contact-dependent growth inhibition (CDI), in which Gram-negative bacteria...