Yuriy Baglaenko
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Explore the profile of Yuriy Baglaenko including associated specialties, affiliations and a list of published articles.
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26
Citations
3683
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Recent Articles
11.
Manion K, Baglaenko Y, Chang N, Talaei N, Wither J
PLoS One
. 2020 Jul;
15(7):e0236664.
PMID: 32722684
Background: Systemic lupus erythematosus (SLE) is a severe autoimmune disease in which immune tolerance defects drive production of pathogenic anti-nuclear autoantibodies. Anergic B cells are considered a potential source of...
12.
TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis
Gracey E, Hromadova D, Lim M, Qaiyum Z, Zeng M, Yao Y, et al.
J Clin Invest
. 2020 Mar;
130(4):1863-1878.
PMID: 32149730
Spondyloarthritis (SpA) represents a family of inflammatory diseases of the spine and peripheral joints. Ankylosing spondylitis (AS) is the prototypic form of SpA in which progressive disease can lead to...
13.
Gutierrez-Arcelus M, Baglaenko Y, Arora J, Hannes S, Luo Y, Amariuta T, et al.
Nat Genet
. 2020 Feb;
52(3):247-253.
PMID: 32066938
Genetic studies have revealed that autoimmune susceptibility variants are over-represented in memory CD4 T cell regulatory elements. Understanding how genetic variation affects gene expression in different T cell physiological states...
14.
Korsunsky I, Millard N, Fan J, Slowikowski K, Zhang F, Wei K, et al.
Nat Methods
. 2019 Nov;
16(12):1289-1296.
PMID: 31740819
The emerging diversity of single-cell RNA-seq datasets allows for the full transcriptional characterization of cell types across a wide variety of biological and clinical conditions. However, it is challenging to...
15.
Luo Y, Suliman S, Asgari S, Amariuta T, Baglaenko Y, Martinez-Bonet M, et al.
Nat Commun
. 2019 Aug;
10(1):3765.
PMID: 31434886
Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5-15% will develop active tuberculosis (TB). Approximately half will progress to active TB within the first 18 months after infection,...
16.
Nathan A, Baglaenko Y, Fonseka C, Beynor J, Raychaudhuri S
Curr Opin Immunol
. 2019 Aug;
61:17-25.
PMID: 31430664
Single-cell methods have revolutionized the study of T cell biology by enabling the identification and characterization of individual cells. This has led to a deeper understanding of T cell heterogeneity...
17.
Baglaenko Y, Chang N, Johnson S, Hafiz W, Manion K, Ferri D, et al.
Arthritis Res Ther
. 2018 Nov;
20(1):264.
PMID: 30486869
Background: Diagnosis of systemic autoimmune rheumatic diseases (SARD) relies on the presence of hallmark anti-nuclear antibodies (ANA), many of which can be detected years before clinical manifestations. However, ANAs are...
18.
Shinde R, Hezaveh K, Halaby M, Kloetgen A, Chakravarthy A, da Silva Medina T, et al.
Nat Immunol
. 2018 May;
19(6):571-582.
PMID: 29760532
The transcription factor AhR modulates immunity at multiple levels. Here we report that phagocytes exposed to apoptotic cells exhibited rapid activation of AhR, which drove production of the cytokine IL-10....
19.
Wu C, Roth T, Baglaenko Y, Ferri D, Brauer P, Zuniga-Pflucker J, et al.
J Immunol Methods
. 2018 Apr;
457:33-40.
PMID: 29614266
Genome editing in human cells with targeted nucleases now enables diverse experimental and therapeutic genome engineering applications, but extension to primary human B cells remains limited. Here we report a...
20.
Chang N, Manion K, Loh C, Pau E, Baglaenko Y, Wither J
PLoS One
. 2017 Jun;
12(6):e0179506.
PMID: 28628673
Lupus is characterized by a loss of B cell tolerance leading to autoantibody production. In this study, we explored the mechanisms underlying this loss of tolerance using B6 congenic mice...