Yuriy Baglaenko
Overview
Explore the profile of Yuriy Baglaenko including associated specialties, affiliations and a list of published articles.
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26
Citations
3683
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Recent Articles
1.
Kotliar D, Curtis M, Agnew R, Weinand K, Nathan A, Baglaenko Y, et al.
bioRxiv
. 2024 May;
PMID: 38746317
T-cells recognize antigens and induce specialized gene expression programs (GEPs) enabling functions including proliferation, cytotoxicity, and cytokine production. Traditionally, different classes of helper T-cells express mutually exclusive responses - for...
2.
Baglaenko Y, Wagner C, Bhoj V, Brodin P, Gershwin M, Graham D, et al.
Camb Prism Precis Med
. 2024 Mar;
1:e25.
PMID: 38550937
Precision Medicine is an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle. Autoimmune diseases are those in which the body's...
3.
Kim T, Martinez-Bonet M, Wang Q, Hackert N, Sparks J, Baglaenko Y, et al.
Nat Commun
. 2024 Mar;
15(1):2150.
PMID: 38459032
Fine-mapping and functional studies implicate rs117701653, a non-coding single nucleotide polymorphism in the CD28/CTLA4/ICOS locus, as a risk variant for rheumatoid arthritis and type 1 diabetes. Here, using DNA pulldown,...
4.
Lin Q, Kuypers M, Baglaenko Y, Cao E, Hezaveh K, Despot T, et al.
Mucosal Immunol
. 2024 Feb;
17(2):226-237.
PMID: 38331095
Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to microbe-derived glycolipid antigens. iNKT cells exert fast innate effector functions that regulate immune responses in a variety...
5.
Wang X, Vigouroux R, Syonov M, Baglaenko Y, Nikolakopoulou A, Ringuette D, et al.
Nat Commun
. 2024 Feb;
15(1):1037.
PMID: 38310100
Liver failure causes breakdown of the Blood CNS Barrier (BCB) leading to damages of the Central-Nervous-System (CNS), however the mechanisms whereby the liver influences BCB-integrity remain elusive. One possibility is...
6.
Xiao Q, Mears J, Nathan A, Ishigaki K, Baglaenko Y, Lim N, et al.
Nat Commun
. 2023 Oct;
14(1):6268.
PMID: 37805522
Psoriasis is a chronic, systemic inflammatory condition primarily affecting skin. While the role of the immune compartment (e.g., T cells) is well established, the changes in the skin compartment are...
7.
Ferri D, Nassar C, Manion K, Kim M, Baglaenko Y, Munoz-Grajales C, et al.
Arthritis Rheumatol
. 2023 Feb;
75(9):1542-1555.
PMID: 36807718
Objective: Elevated levels of serum interferon-α (IFNα) and the disruption of B cell tolerance are central to systemic lupus erythematosus (SLE) immunopathogenesis; however, the relationship between these 2 processes remains...
8.
Nathan A, Asgari S, Ishigaki K, Valencia C, Amariuta T, Luo Y, et al.
Nature
. 2022 May;
606(7912):120-128.
PMID: 35545678
Non-coding genetic variants may cause disease by modulating gene expression. However, identifying these expression quantitative trait loci (eQTLs) is complicated by differences in gene regulation across fluid functional cell states...
9.
Baglaenko Y, Macfarlane D, Marson A, Nigrovic P, Raychaudhuri S
Nat Rev Rheumatol
. 2021 Jun;
17(8):462-474.
PMID: 34188205
Discoveries in human genetic studies have revolutionized our understanding of complex rheumatic and autoimmune diseases, including the identification of hundreds of genetic loci and single nucleotide polymorphisms that potentially predispose...
10.
Nathan A, Beynor J, Baglaenko Y, Suliman S, Ishigaki K, Asgari S, et al.
Nat Immunol
. 2021 May;
22(6):781-793.
PMID: 34031617
Multimodal T cell profiling can enable more precise characterization of elusive cell states underlying disease. Here, we integrated single-cell RNA and surface protein data from 500,089 memory T cells to...