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» Authors » Yuriy Alexandrov

Yuriy Alexandrov

Explore the profile of Yuriy Alexandrov including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 23
Citations 321
Followers 0
Related Specialties
Science
General Medicine
Radiology
Top 10 Co-Authors
Paul M W French
Sunil Kumar
James Mcginty
Chris Dunsby
Christopher Dunsby
Mark A A Neil
Ian Munro
Clifford Talbot
Douglas J Kelly
Frederik Gorlitz
Published In
J Biophotonics
PLoS One
Biomed Opt Express
Assay Drug Dev Technol
Sci Rep
Affiliations
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Recent Articles
1.
Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways
Guglielmi L, Heliot C, Kumar S, Alexandrov Y, Gori I, Papaleonidopoulou F, et al.
Nat Commun . 2021 Nov; 12(1):6374. PMID: 34737283
The transcriptional effector SMAD4 is a core component of the TGF-β family signaling pathways. However, its role in vertebrate embryo development remains unresolved. To address this, we deleted Smad4 in...
2.
Single-shot phase contrast microscopy using polarisation-resolved differential phase contrast
Kalita R, Flanagan W, Lightley J, Kumar S, Alexandrov Y, Garcia E, et al.
J Biophotonics . 2021 Aug; 14(12):e202100144. PMID: 34390220
We present a robust, low-cost single-shot implementation of differential phase microscopy utilising a polarisation-sensitive camera to simultaneously acquire four images from which phase contrast images can be calculated. This polarisation-resolved...
3.
Robust deep learning optical autofocus system applied to automated multiwell plate single molecule localization microscopy
Lightley J, Gorlitz F, Kumar S, Kalita R, Kolbeinsson A, Garcia E, et al.
J Microsc . 2021 Jun; 288(2):130-141. PMID: 34089183
We presenta robust, long-range optical autofocus system for microscopy utilizing machine learning. This can be useful for experiments with long image data acquisition times that may be impacted by defocusing...
4.
Application of direct stochastic optical reconstruction microscopy (dSTORM) to the histological analysis of human glomerular disease
Garcia E, Lightley J, Kumar S, Kalita R, Gorlitz F, Alexandrov Y, et al.
J Pathol Clin Res . 2021 May; 7(5):438-445. PMID: 34018698
Electron microscopy (EM) following immunofluorescence (IF) imaging is a vital tool for the diagnosis of human glomerular diseases, but the implementation of EM is limited to specialised institutions and it...
5.
DDR1 autophosphorylation is a result of aggregation into dense clusters
Corcoran D, Juskaite V, Xu Y, Gorlitz F, Alexandrov Y, Dunsby C, et al.
Sci Rep . 2019 Nov; 9(1):17104. PMID: 31745115
The collagen receptor DDR1 is a receptor tyrosine kinase that promotes progression of a wide range of human disorders. Little is known about how ligand binding triggers DDR1 kinase activity....
6.
Convolutional neural networks for reconstruction of undersampled optical projection tomography data applied to in vivo imaging of zebrafish
Davis S, Kumar S, Alexandrov Y, Bhargava A, da Silva Xavier G, Rutter G, et al.
J Biophotonics . 2019 Aug; 12(12):e201900128. PMID: 31386281
Optical projection tomography (OPT) is a 3D mesoscopic imaging modality that can utilize absorption or fluorescence contrast. 3D images can be rapidly reconstructed from tomographic data sets sampled with sufficient...
7.
Automated Fluorescence Lifetime Imaging High-Content Analysis of Förster Resonance Energy Transfer between Endogenously Labeled Kinetochore Proteins in Live Budding Yeast Cells
Guo W, Kumar S, Gorlitz F, Garcia E, Alexandrov Y, Munro I, et al.
SLAS Technol . 2019 Jan; 24(3):308-320. PMID: 30629461
We describe an open-source automated multiwell plate fluorescence lifetime imaging (FLIM) methodology to read out Förster resonance energy transfer (FRET) between fluorescent proteins (FPs) labeling endogenous kinetochore proteins (KPs) in...
8.
Performance of a wearable acoustic system for fetal movement discrimination
Lai J, Woodward R, Alexandrov Y, Ain Munnee Q, Lees C, Vaidyanathan R, et al.
PLoS One . 2018 May; 13(5):e0195728. PMID: 29734344
Fetal movements (FM) are a key factor in clinical management of high-risk pregnancies such as fetal growth restriction. While maternal perception of reduced FM can trigger self-referral to obstetric services,...
9.
Quantitative time domain analysis of lifetime-based Förster resonant energy transfer measurements with fluorescent proteins: Static random isotropic fluorophore orientation distributions
Alexandrov Y, Nikolic D, Dunsby C, French P
J Biophotonics . 2018 Mar; 11(7):e201700366. PMID: 29582566
Förster resonant energy transfer (FRET) measurements are widely used to obtain information about molecular interactions and conformations through the dependence of FRET efficiency on the proximity of donor and acceptor...
10.
In vivo multiphoton microscopy using a handheld scanner with lateral and axial motion compensation
Sherlock B, Warren S, Alexandrov Y, Yu F, Stone J, Knight J, et al.
J Biophotonics . 2017 Sep; 11(2). PMID: 28858435
This paper reports a handheld multiphoton fluorescence microscope designed for clinical imaging that incorporates axial motion compensation and lateral image stabilization. Spectral domain optical coherence tomography is employed to track...