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James Mcginty

Explore the profile of James Mcginty including associated specialties, affiliations and a list of published articles. Areas
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Articles 52
Citations 1341
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Recent Articles
1.
Zhang M, Li R, Fu S, Kumar S, Mcginty J, Qin Y, et al.
Light Sci Appl . 2025 Feb; 14(1):92. PMID: 39994185
Time-resolved volumetric fluorescence imaging over an extended duration with high spatial/temporal resolution is a key driving force in biomedical research for investigating spatial-temporal dynamics at organism-level systems, yet it remains...
2.
Gleneadie H, Fernandez-Ruiz B, Sardini A, Van de Pette M, Dimond A, Prinjha R, et al.
Commun Biol . 2023 Mar; 6(1):318. PMID: 36966198
Duchenne muscular dystrophy (DMD) is an X-linked disorder caused by loss of function mutations in the dystrophin gene (Dmd), resulting in progressive muscle weakening. Here we modelled the longitudinal expression...
3.
Darling C, Davis S, Kumar S, French P, Mcginty J
J Biophotonics . 2022 Sep; 16(2):e202200232. PMID: 36087031
A single-shot adaptation of Optical Projection Tomography (OPT) for high-speed volumetric snapshot imaging of dynamic mesoscopic biological samples is presented. Conventional OPT has been applied to in vivo imaging of...
4.
Van de Pette M, Dimond A, Galvao A, Millership S, To W, Prodani C, et al.
Nat Commun . 2022 May; 13(1):2464. PMID: 35513363
Transmission of epigenetic information between generations occurs in nematodes, flies and plants, mediated by specialised small RNA pathways, modified histones and DNA methylation. Similar processes in mammals can also affect...
5.
Guglielmi L, Heliot C, Kumar S, Alexandrov Y, Gori I, Papaleonidopoulou F, et al.
Nat Commun . 2021 Nov; 12(1):6374. PMID: 34737283
The transcriptional effector SMAD4 is a core component of the TGF-β family signaling pathways. However, its role in vertebrate embryo development remains unresolved. To address this, we deleted Smad4 in...
6.
Davis S, Kumar S, Alexandrov Y, Bhargava A, da Silva Xavier G, Rutter G, et al.
J Biophotonics . 2019 Aug; 12(12):e201900128. PMID: 31386281
Optical projection tomography (OPT) is a 3D mesoscopic imaging modality that can utilize absorption or fluorescence contrast. 3D images can be rapidly reconstructed from tomographic data sets sampled with sufficient...
7.
Baboumian S, Pantazatos S, Kothari S, Mcginty J, Holst J, Geliebter A
Neuroscience . 2019 Feb; 409:290-298. PMID: 30769095
Of current obesity treatments, bariatric surgery induces the most weight loss. Given the marked increase in the number of bariatric surgeries performed, elucidating the mechanisms of action is a key...
8.
Shah A, Holter M, Rimawi F, Mark V, Dutia R, Mcginty J, et al.
Diabetes Care . 2018 Dec; 42(2):311-317. PMID: 30523032
Objective: Hepatic insulin clearance is a significant regulator of glucose homestasis. We hypothesized that the improvement in insulin clearance rates (ICRs) under fasting conditions and in response to oral and...
9.
Davis S, Wisniewski L, Kumar S, Correia T, Arridge S, Frankel P, et al.
Opt Lett . 2018 Nov; 43(22):5555-5558. PMID: 30439894
To improve the imaging performance of optical projection tomography (OPT) in live samples, we have explored a parallelized implementation of semi-confocal line illumination and detection to discriminate against scattered photons....
10.
Chen L, Li G, Tang L, Zhang M, Liu L, Liu A, et al.
J Biophotonics . 2018 Sep; 12(4):e201800221. PMID: 30187691
In order to study physical relationships within tissue volumes or even organism-level systems, the spatial distribution of multiple fluorescent markers needs to be resolved efficiently in three dimensions. Here, rather...